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BD Caspase-3
Play key role in normal apoptosis during development induced by the death receptors
Supplier: BD 556472
Description
Caspases are cysteine proteases that play central role in apoptosis. The caspase family was discovered by searching human cDNA libraries for sequences homologous to ced-3, a C. Each caspase is synthesized as an inactive proenzyme that is processed by cleavage at asparte residues by another protease or by self-proteolysis.
- Fas and tumor necrosis factor receptor type 1 (TNFR1)
- One of their substrates is poly (ADP ribose) polymerase (PARP)
- Cleave PARP from its 116kDa form to 85kDa residual fragment
- The cleavage site in PARP is C-terminal to Asp-216
- Utilized as basis for highly specific caspase-3 substrates such as Ac(N-acetyl)-DEVD-AFC (7-amino-4-trifluoromethylcourmarin) and Ac(N-acetyl)-DEVD-AMC (7-amino-4-methylcoumarin) as well as caspase-3 aldehyde inhibitor Ac-DEVD-CHO
- Storage Buffer: 50mM Tris (pH 8.0) with 100mM NaCl and 50mM imidazole
- Format: Purified
Specifications
0.2mg/mL | |
50mM Tris (pH 8) with 100mM NaCl and 50mM Imidazole | |
5μg | |
Human | |
Purified |
Enzyme Assay | |
Human Caspase-3 Active Form Recombinant Protein | |
-80°C | |
Recombinant |
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