Hs01103275_cn

• Gene Symbol: TDG
• Assay Reference Genome Location: Chr.12:103980917 on build GRCh38
• Cytoband: 12q23.3

Target Gene Details

• Entrez Gene ID: 6996
• Gene Name: thymine DNA glycosylase
• Gene Aliases: hTDG
• Location: Chr.12:103965815-103988878 on Build GRCh38
• Assay Gene Location: Overlaps Intron 3 - Exon 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TDG	NM_003211.4			NP_003202.3
	XM_005269125.1			XP_005269182.1
	XM_011538714.1			XP_011537016.1
	XM_011538715.1			XP_011537017.1
	AK295387.1
	AK303631.1
	AK309792.1
	AK313234.1
	AL710869.1
	BC019925.1
	BC037557.1			AAH37557.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv560039	Chr.12:103783890 - 104061562 on Build GRCh38	Gain	MIR3652 HSP90B1 C12orf73 TTC41P NT5DC3 TDG GLT8D2
esv2746303	Chr.12:103980022 - 103982808 on Build GRCh38	Deletion	TDG

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA metabolism protein, DNA glycosylase, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
base-excision repair
base-excision repair, AP site formation
mismatch repair
transcription, DNA-templated
embryo development
covalent chromatin modification
protein sumoylation
negative regulation of protein binding
oxidative DNA demethylation
negative regulation of chromatin binding
regulation of gene expression, epigenetic
depyrimidination
DNA demethylation

Function(s)

RNA polymerase II transcription cofactor activity
damaged DNA binding
double-stranded DNA binding
uracil DNA N-glycosylase activity
protein kinase C binding
protein binding
pyrimidine-specific mismatch base pair DNA N-glycosylase activity
DNA N-glycosylase activity
mismatched DNA binding
SUMO binding
protein homodimerization activity
structure-specific DNA binding