Hs01976430_cn

• Gene Symbol: NR1D1
• Assay Reference Genome Location: Chr.17:40100093 on build GRCh38
• Cytoband: 17q21.1

Target Gene Details

• Entrez Gene ID: 9572
• Gene Name: nuclear receptor subfamily 1 group D member 1
• Gene Aliases: EAR1, THRA1, THRAL, ear-1, hRev
• Location: Chr.17:40092784-40100725 on Build GRCh38
• Assay Gene Location: Overlaps Intron 1 - Exon 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NR1D1	NM_021724.4			NP_068370.1
	AK300155.1
	AK315270.1
	BC047875.1
	BC056148.1			AAH56148.1
	HQ692861.1
	M24898.1			AAA52335.1
	M34339.1			AAA36561.1
	X72631.1			CAB53540.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv520636	Chr.17:40098436 - 40107944 on Build GRCh38	Loss	NR1D1
nsv833444	Chr.17:40086570 - 40281028 on Build GRCh38	Loss	WIPF2 CASC3 THRA RAPGEFL1 NR1D1 MSL1 MIR6866 MIR6867

More Information

• Set Membership: Intragenic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor, DNA-binding transcription factor, zinc finger transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
glycogen biosynthetic process
transcription initiation from RNA polymerase II promoter
circadian rhythm
proteasomal protein catabolic process
negative regulation of receptor biosynthetic process
regulation of lipid metabolic process
cell differentiation
intracellular receptor signaling pathway
circadian regulation of gene expression
negative regulation of toll-like receptor 4 signaling pathway
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
regulation of circadian rhythm
steroid hormone mediated signaling pathway
response to leptin
regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
circadian temperature homeostasis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of type B pancreatic cell proliferation
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
regulation of cholesterol homeostasis
positive regulation of cholesterol homeostasis

Function(s)

RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription corepressor binding
steroid hormone receptor activity
transcription corepressor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
heme binding
transcription regulatory region DNA binding