Hs03368294_cn

• Gene Symbol: NOC2L
• Assay Reference Genome Location: Chr.1:951680 on build GRCh38
• Cytoband: 1p36.33

Target Gene Details

• Entrez Gene ID: 26155
• Gene Name: NOC2 like nucleolar associated transcriptional repressor
• Gene Aliases: NET15, NET7, NIR, PPP1R112
• Location: Chr.1:944203-959299 on Build GRCh38
• Assay Gene Location: Within Intron 11

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
NOC2L	NM_015658.3			NP_056473.2
	AK022756.1			BAB14230.1
	AK024284.1
	AK225239.1
	AK315080.1
	AL050019.1			CAB43240.2
	AW749585.1
	BC003555.1			AAH03555.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
esv2762302	Chr.1:914637 - 1106320 on Build GRCh38	Gain	RNF223 C1orf159 SAMD11 LOC107985728 NOC2L LOC100130417 HES4 LOC100288175 AGRN KLHL17 PLEKHN1 PERM1 LOC284600 ISG15 LOC105378948
nsv482937	Chr.1:10001 - 2368561 on Build GRCh38	Loss	RNF223 MXRA8 LOC107984841 NOC2L MIR1302-2 LOC100288175 MIR200B CPSF3L PERM1 MMP23B SDF4 OR4F5 ISG15 LOC107985729 LOC729737 SAMD11 FAM87B MIR6727 MRPL20 LOC105378947 LOC100130417 ATAD3A MIR429 AGRN FAAP20 CFAP74 GABRD OR4F29 CALML6 CCNL2 TAS1R3 LOC100133331 LOC102725121 TNFRSF4 MTND2P28 LOC105378591 C1orf159 MORN1 VWA1 LOC100287934 NADK LOC107985728 ATAD3B UBE2J2 LOC100506504 GNB1 ACAP3 SKI MIR6808 LOC105378592 TTLL10 TTLL10-AS1 MIB2 PRKCZ LOC100134822 CPTP LINC01128 KLHL17 DVL1 MIR6859-1 TNFRSF18 FAM132A ATAD3C LINC01342 LOC105378948 LOC100288069 WASH7P SCNN1D HES4 LOC102724312 LOC148413 LOC105378949 SLC35E2B LOC100129534 ANKRD65 SSU72 LOC101928626 MMP23A MIR6859-2 MIR200A PLEKHN1 FAM41C MIR6726 DDX11L1 B3GALT6 FNDC10 FAM138A LOC284600 AURKAIP1 LINC00115 MIR6723 CDK11A OR4F16 LOC105378589 CDK11B TMEM240 TMEM88B MTND1P23 LOC100132287 TMEM52 SLC35E2 PUSL1
nsv950451	Chr.1:899421 - 1094520 on Build GRCh38	Deletion	RNF223 C1orf159 SAMD11 LOC107985728 NOC2L LOC100130417 HES4 LOC100288175 AGRN KLHL17 PLEKHN1 PERM1 LOC284600 ISG15 LOC105378948
nsv509035	Chr.1:891406 - 985724 on Build GRCh38	Insertion	KLHL17 SAMD11 PLEKHN1 PERM1 LOC107985728 NOC2L LOC100130417 LOC284600
dgv9n54	Chr.1:925754 - 952840 on Build GRCh38	Loss	SAMD11 NOC2L
nsv428334	Chr.1:874371 - 1220569 on Build GRCh38	Gain	RNF223 TTLL10-AS1 NOC2L LOC100288175 MIR200B MIR200A KLHL17 PLEKHN1 FAM41C TNFRSF4 PERM1 TNFRSF18 SDF4 LOC284600 LINC01342 ISG15 LOC105378948 C1orf159 SAMD11 LOC107985728 LOC100130417 HES4 MIR429 AGRN TTLL10
nsv10161	Chr.1:776731 - 1777210 on Build GRCh38	Gain+Loss	RNF223 MXRA8 TTLL10-AS1 MIB2 CPTP NOC2L LOC100288175 LINC01128 MIR200B CPSF3L KLHL17 PERM1 MMP23B DVL1 TNFRSF18 FAM132A SDF4 ATAD3C LINC01342 ISG15 LOC105378948 LOC100288069 LOC107985729 SCNN1D SAMD11 FAM87B MIR6727 MRPL20 LOC100130417 HES4 LOC102724312 LOC148413 ATAD3A MIR429 AGRN SLC35E2B CCNL2 ANKRD65 SSU72 TAS1R3 MMP23A MIR200A PLEKHN1 FAM41C TNFRSF4 MIR6726 B3GALT6 FNDC10 LOC284600 AURKAIP1 C1orf159 VWA1 LOC100287934 LINC00115 NADK CDK11A LOC107985728 ATAD3B UBE2J2 ACAP3 CDK11B TMEM240 TMEM88B MIR6808 TTLL10 SLC35E2 PUSL1
dgv5n100	Chr.1:585989 - 1114424 on Build GRCh38	Gain	RNF223 LOC107984841 NOC2L LOC101928626 LOC100288175 LOC100133331 LINC01128 KLHL17 PLEKHN1 FAM41C MTND2P28 PERM1 LOC284600 ISG15 LOC105378948 LOC100288069 C1orf159 LOC100287934 LINC00115 MIR6723 SAMD11 FAM87B OR4F16 LOC107985728 LOC105378947 LOC100130417 HES4 AGRN MTND1P23
nsv517709	Chr.1:817186 - 1275912 on Build GRCh38	Gain+Loss	RNF223 TTLL10-AS1 NOC2L LOC100288175 LINC01128 MIR200B MIR200A KLHL17 PLEKHN1 FAM41C TNFRSF4 B3GALT6 PERM1 TNFRSF18 FAM132A SDF4 LOC284600 LINC01342 ISG15 LOC105378948 C1orf159 LINC00115 SAMD11 FAM87B LOC107985728 LOC100130417 HES4 UBE2J2 MIR429 AGRN TTLL10
nsv1013524	Chr.1:939510 - 1161955 on Build GRCh38	Gain	RNF223 C1orf159 SAMD11 NOC2L HES4 LOC100288175 AGRN KLHL17 PLEKHN1 PERM1 LINC01342 ISG15 LOC105378948
nsv1160644	Chr.1:939652 - 1220663 on Build GRCh38	Deletion	RNF223 C1orf159 SAMD11 TTLL10-AS1 NOC2L HES4 LOC100288175 MIR429 AGRN MIR200B MIR200A KLHL17 PLEKHN1 TNFRSF4 PERM1 TNFRSF18 SDF4 LINC01342 ISG15 TTLL10 LOC105378948
nsv544895	Chr.1:917392 - 1054900 on Build GRCh38	Loss	KLHL17 SAMD11 PLEKHN1 PERM1 LOC107985728 NOC2L LOC100130417 HES4 LOC284600 ISG15 AGRN
dgv2n67	Chr.1:877618 - 1426500 on Build GRCh38	Gain	RNF223 MXRA8 TTLL10-AS1 TAS1R3 CPTP NOC2L LOC100288175 MIR200B CPSF3L MIR200A KLHL17 PLEKHN1 TNFRSF4 MIR6726 B3GALT6 PERM1 DVL1 TNFRSF18 FAM132A SDF4 LOC284600 LINC01342 ISG15 LOC105378948 AURKAIP1 C1orf159 SCNN1D SAMD11 MIR6727 MRPL20 LOC107985728 LOC100130417 HES4 LOC148413 UBE2J2 MIR429 AGRN ACAP3 TMEM88B MIR6808 CCNL2 TTLL10 PUSL1 ANKRD65
nsv832980	Chr.1:848279 - 1007037 on Build GRCh38	Gain	KLHL17 SAMD11 PLEKHN1 FAM41C PERM1 LOC107985728 NOC2L LOC100130417 HES4 LINC01128 LOC284600

More Information

Additional Information:

For this assay, SNP(s) [rs74045018,rs76456117] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
negative regulation of B cell apoptotic process
transcription, DNA-templated
apoptotic process
chromatin assembly
nucleolus to nucleoplasm transport
cellular response to UV
negative regulation of histone acetylation
ribosomal large subunit biogenesis
regulation of signal transduction by p53 class mediator
negative regulation of intrinsic apoptotic signaling pathway

Function(s)

chromatin binding
transcription corepressor activity
protein binding
nucleosome binding
histone binding
poly(A) RNA binding
repressing transcription factor binding