Hs02146753_cn

• Gene Symbol: DNMT1
• Assay Reference Genome Location: Chr.19:10136207 on build GRCh38
• Cytoband: 19p13.2

Target Gene Details

• Entrez Gene ID: 1786
• Gene Name: DNA (cytosine-5-)-methyltransferase 1
• Gene Aliases: ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
• Location: Chr.19:10133344-10195135 on Build GRCh38
• Assay Gene Location: Within Exon 38

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
DNMT1	NM_001130823.2	38	4806	NP_001124295.1
	NM_001318730.1	37	4686	NP_001305659.1
	NM_001318731.1	38	4685	NP_001305660.1
	NM_001379.3	37	4758	NP_001370.1
	AB209413.2	37	4493	BAD92650.1
	AF180682.1	35	4265	AAF23609.1
	AK122759.1	10	2442
	BC126227.1	38	4750
	BC144093.1	38	4750
	X63692.1	37	4759	CAA45219.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv833743	Chr.19:10077649 - 10251913 on Build GRCh38	Loss	PPAN SNORD105 EIF3G MIR4322 DNMT1 PPAN-P2RY11 ANGPTL6 SNORD105B C19orf66 P2RY11

More Information

• Set Membership: Intragenic, Exonic, DGV Variation

Panther Classification:

Molecular Function -

DNA metabolism protein, DNA methyltransferase, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA methylation
transcription, DNA-templated
Ras protein signal transduction
brain development
aging
response to heat
response to toxic substance
response to ionizing radiation
maintenance of DNA methylation
DNA methylation on cytosine within a CG sequence
positive regulation of gene expression
response to activity
gene silencing
covalent chromatin modification
neuron differentiation
response to caffeine
response to estradiol
response to lipopolysaccharide
response to vitamin A
response to testosterone
cellular response to platelet-derived growth factor stimulus
response to antidepressant
regulation of cell proliferation
DNA hypermethylation
response to ethanol
negative regulation of gene expression, epigenetic
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to amino acid stimulus
cellular response to lead ion
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
positive regulation of methylation-dependent chromatin silencing
cellular response to nerve growth factor stimulus

Function(s)

DNA binding
double-stranded DNA binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
zinc ion binding
methyl-CpG binding
DNA-methyltransferase activity
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates
promoter-specific chromatin binding