Hs03557737_cn

• Gene Symbol: PLEKHG4B
• Assay Reference Genome Location: Chr.5:75112 on build GRCh38
• Cytoband: 5p15.33

Target Gene Details

• Entrez Gene ID: 153478
• Gene Name: pleckstrin homology and RhoGEF domain containing G4B
• Gene Aliases: -
• Location: Chr.5:54065-189972 on Build GRCh38
• Assay Gene Location: Within Intron 1

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PLEKHG4B	XM_011513971.2			XP_011512273.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv822925	Chr.5:49928 - 185592 on Build GRCh38	Gain	PLEKHG4B
esv2752083	Chr.5:28951 - 346521 on Build GRCh38	Gain	LRRC14B SDHA AHRR PLEKHG4B CCDC127 HRAT5 PDCD6
esv3603729	Chr.5:74519 - 76683 on Build GRCh38	Loss	PLEKHG4B
dgv5519n100	Chr.5:71184 - 138345 on Build GRCh38	Gain	PLEKHG4B
dgv5514n100	Chr.5:15520 - 138345 on Build GRCh38	Gain	PLEKHG4B
nsv10643	Chr.5:59149 - 119560 on Build GRCh38	Gain+Loss	PLEKHG4B
nsv509040	Chr.5:59249 - 86835 on Build GRCh38	Insertion	PLEKHG4B
esv3603727	Chr.5:74460 - 122563 on Build GRCh38	Loss	PLEKHG4B
dgv5518n100	Chr.5:63270 - 115984 on Build GRCh38	Gain	PLEKHG4B
nsv1031835	Chr.5:46687 - 138345 on Build GRCh38	Gain	PLEKHG4B
esv2677502	Chr.5:74577 - 76650 on Build GRCh38	Deletion	PLEKHG4B
esv3603720	Chr.5:40419 - 176322 on Build GRCh38	Loss	PLEKHG4B
esv2759315	Chr.5:17263 - 595840 on Build GRCh38	Loss	SLC9A3 SDHA EXOC3-AS1 MIR4456 EXOC3 LOC100288152 PP7080 LRRC14B AHRR PLEKHG4B CCDC127 HRAT5 PDCD6
nsv461885	Chr.5:27565 - 118291 on Build GRCh38	Gain	PLEKHG4B
dgv5517n100	Chr.5:19572 - 164078 on Build GRCh38	Loss	PLEKHG4B
dgv9471n54	Chr.5:12225 - 141544 on Build GRCh38	Loss	PLEKHG4B
dgv5516n100	Chr.5:17630 - 81382 on Build GRCh38	Loss	PLEKHG4B
esv26253	Chr.5:73864 - 76275 on Build GRCh38	Loss	PLEKHG4B
nsv950616	Chr.5:71286 - 94685 on Build GRCh38	Deletion	PLEKHG4B
nsv441935	Chr.5:68560 - 115996 on Build GRCh38	Gain	PLEKHG4B

More Information

Additional Information:

For this assay, SNP(s) [rs73018514] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

guanyl-nucleotide exchange factor

Gene Ontology Categories:

Process(es)

regulation of Rho protein signal transduction
positive regulation of GTPase activity

Function(s)

Rho guanyl-nucleotide exchange factor activity
protein binding