Hs03685687_cn

• Gene Symbol: PARP10
• Assay Reference Genome Location: Chr.8:143979322 on build GRCh38
• Cytoband: 8q24.3

Target Gene Details

• Entrez Gene ID: 84875
• Gene Name: poly(ADP-ribose) polymerase family member 10
• Gene Aliases: ARTD10
• Location: Chr.8:143977152-143986471 on Build GRCh38
• Assay Gene Location: Within Intron 8

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
PARP10	NM_001317895.1			NP_001304824.1
	NM_032789.4			NP_116178.2
	NR_134234.1
	XM_011517336.2			XP_011515638.1
	AK027370.1			BAB55067.1
	AK075250.1			BAC11498.1
	AK124017.1
	AK128537.1
	AK129821.1
	AK222914.1			BAD96634.1
	AK303317.1
	BC014229.2			AAH14229.2
	BC019030.2			AAH19030.2
	BC132961.1
	BC136542.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv6445	Chr.8:143961415 - 143994522 on Build GRCh38	Insertion	PARP10 GRINA PLEC
nsv470249	Chr.8:143889098 - 144519234 on Build GRCh38	Loss	EXOSC4 CYHR1 MIR6849 CPSF1 SHARPIN RECQL4 GPAA1 MIR1234 BOP1 MIR661 SPATC1 MIR6848 MFSD3 TONSL-AS1 PPP1R16A PARP10 ADCK5 MIR6847 SCRT1 DGAT1 LOC101928902 SMPD5 LOC101928953 MAF1 OPLAH GRINA TMEM249 FOXH1 GPT MIR6893 KIFC2 LRRC14 SLC39A4 MROH1 CYC1 PLEC HGH1 SLC52A2 MIR7112 WDR97 TONSL MIR6846 MIR939 VPS28 HSF1 SCX FBXL6
nsv515809	Chr.8:143904439 - 144519234 on Build GRCh38	Gain+Loss	EXOSC4 CYHR1 MIR6849 CPSF1 SHARPIN RECQL4 GPAA1 MIR1234 BOP1 MIR661 SPATC1 MIR6848 MFSD3 TONSL-AS1 PPP1R16A PARP10 ADCK5 MIR6847 SCRT1 DGAT1 LOC101928902 SMPD5 LOC101928953 MAF1 OPLAH GRINA TMEM249 FOXH1 GPT MIR6893 KIFC2 LRRC14 SLC39A4 MROH1 CYC1 PLEC HGH1 SLC52A2 MIR7112 WDR97 TONSL MIR6846 MIR939 VPS28 HSF1 SCX FBXL6
nsv612914	Chr.8:143972494 - 144120626 on Build GRCh38	Loss	EXOSC4 SHARPIN GPAA1 CYC1 SPATC1 PLEC PARP10 MIR6847 WDR97 MIR6846 SMPD5 MAF1 OPLAH GRINA
dgv12431n54	Chr.8:143845100 - 144161320 on Build GRCh38	Loss	EXOSC4 EPPK1 SHARPIN GPAA1 MROH1 MIR661 CYC1 SPATC1 PLEC HGH1 PARP10 MIR6847 WDR97 MIR6846 SMPD5 MAF1 OPLAH GRINA
nsv950015	Chr.8:143866633 - 144125597 on Build GRCh38	Deletion	EXOSC4 EPPK1 SHARPIN GPAA1 MIR661 CYC1 SPATC1 PLEC PARP10 MIR6847 WDR97 MIR6846 SMPD5 MAF1 OPLAH GRINA
nsv1161815	Chr.8:143775169 - 144080674 on Build GRCh38	Deletion	EXOSC4 PUF60 MIR937 EPPK1 NRBP2 MIR661 SPATC1 LOC642574 PLEC PARP10 MIR6845 MIR6847 MIR6846 SMPD5 OPLAH SCRIB GRINA
nsv470250	Chr.8:143917934 - 144097007 on Build GRCh38	Gain	PARP10 EXOSC4 MIR6847 GPAA1 MIR6846 SMPD5 OPLAH MIR661 GRINA CYC1 SPATC1 PLEC
dgv12433n54	Chr.8:143902404 - 144120626 on Build GRCh38	Gain	EXOSC4 SHARPIN GPAA1 MIR661 CYC1 SPATC1 PLEC PARP10 MIR6847 WDR97 MIR6846 SMPD5 MAF1 OPLAH GRINA
nsv612906	Chr.8:143917935 - 144090784 on Build GRCh38	Loss	PARP10 EXOSC4 MIR6847 GPAA1 MIR6846 SMPD5 OPLAH MIR661 GRINA SPATC1 PLEC

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

protein ADP-ribosylation
negative regulation of gene expression
regulation of chromatin assembly
negative regulation of NF-kappaB transcription factor activity
negative regulation of protein import into nucleus, translocation
negative regulation of viral genome replication
negative regulation of fibroblast proliferation
protein poly-ADP-ribosylation
protein auto-ADP-ribosylation
negative regulation of protein K63-linked ubiquitination

Function(s)

NAD+ ADP-ribosyltransferase activity
protein binding
K63-linked polyubiquitin binding