Hs04033882_cn

• Gene Symbol: STK11
• Assay Reference Genome Location: Chr.19:1219948 on build GRCh38
• Cytoband: 19p13.3

Target Gene Details

• Entrez Gene ID: 6794
• Gene Name: serine/threonine kinase 11
• Gene Aliases: LKB1, PJS, hLKB1
• Location: Chr.19:1205799-1228435 on Build GRCh38
• Assay Gene Location: Within Intron 4

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
STK11	NM_000455.4			NP_000446.1
	XM_005259617.2			XP_005259674.1
	XM_005259618.3			XP_005259675.1
	XM_011528209.1			XP_011526511.1
	AB209553.1			BAD92790.1
	AF035625.1			AAC39527.1
	AF217978.1			AAG17221.1
	AK314858.1
	BC007981.2			AAH07981.1
	BC019334.1			AAH19334.1
	EF644172.1
	KU178339.1
	KU178340.1
	U63333.1			AAB05809.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv1058677	Chr.19:1054061 - 1283189 on Build GRCh38	Loss	CIRBP C19orf24 ATP5D EFNA2 CBARP LOC102725180 POLR2E SBNO2 ABCA7 CIRBP-AS1 STK11 ARHGAP45 GPX4 MIDN
dgv136n111	Chr.19:1038223 - 1329640 on Build GRCh38	Deletion	CIRBP C19orf24 ATP5D EFNA2 CBARP CNN2 LOC102725180 POLR2E SBNO2 ABCA7 CIRBP-AS1 STK11 ARHGAP45 GPX4 MIDN
nsv9662	Chr.19:893394 - 1317740 on Build GRCh38	Gain	KISS1R CIRBP TMEM259 C19orf24 ATP5D EFNA2 CBARP CNN2 WDR18 LOC102725180 POLR2E GRIN3B RNU6-2 SBNO2 ABCA7 CIRBP-AS1 RNU6-9 R3HDM4 STK11 LOC105372235 ARHGAP45 GPX4 ARID3A MIDN
nsv470104	Chr.19:1170446 - 1325151 on Build GRCh38	Loss	CIRBP SBNO2 C19orf24 CIRBP-AS1 ATP5D STK11 EFNA2 CBARP LOC102725180 MIDN
nsv1160555	Chr.19:887275 - 1346084 on Build GRCh38	Deletion	KISS1R CIRBP C19orf24 CNN2 MED16 LOC102725180 GRIN3B RNU6-2 ABCA7 CIRBP-AS1 R3HDM4 STK11 GPX4 ARID3A TMEM259 ATP5D EFNA2 CBARP WDR18 POLR2E SBNO2 RNU6-9 LOC105372235 ARHGAP45 MIDN
nsv953941	Chr.19:1205602 - 1322401 on Build GRCh38	Deletion	CIRBP C19orf24 CIRBP-AS1 ATP5D STK11 EFNA2 CBARP MIDN
nsv470103	Chr.19:1086044 - 1325151 on Build GRCh38	Gain	CIRBP C19orf24 ATP5D EFNA2 CBARP LOC102725180 POLR2E SBNO2 CIRBP-AS1 STK11 ARHGAP45 GPX4 MIDN
esv2758743	Chr.19:951641 - 1544934 on Build GRCh38	Gain+Loss	CIRBP C19orf24 CNN2 LOC102725180 PLK5 ADAMTSL5 GRIN3B RNU6-2 APC2 ABCA7 CIRBP-AS1 STK11 GPX4 ARID3A REEP6 NDUFS7 GAMT C19orf25 TMEM259 MUM1 RPS15 ATP5D DAZAP1 EFNA2 CBARP WDR18 POLR2E SBNO2 PCSK4 LOC105372235 ARHGAP45 MIDN

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

regulation of cell growth
tissue homeostasis
vasculature development
protein phosphorylation
autophagy
cellular response to DNA damage stimulus
cell cycle arrest
spermatid development
axonogenesis
negative regulation of cell proliferation
response to ionizing radiation
positive regulation of autophagy
establishment of cell polarity
regulation of Wnt signaling pathway
negative regulation of cell growth
positive regulation of transforming growth factor beta receptor signaling pathway
activation of protein kinase activity
TCR signalosome assembly
glucose homeostasis
anoikis
positive thymic T cell selection
protein autophosphorylation
regulation of dendrite morphogenesis
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of axonogenesis
T cell receptor signaling pathway
negative regulation of lipid biosynthetic process
Golgi localization
regulation of protein kinase B signaling
canonical Wnt signaling pathway
negative regulation of epithelial cell proliferation involved in prostate gland development
cellular response to UV-B
positive regulation of protein serine/threonine kinase activity
intrinsic apoptotic signaling pathway by p53 class mediator
dendrite extension
positive regulation of protein localization to nucleus
regulation of signal transduction by p53 class mediator
negative regulation of TORC1 signaling

Function(s)

magnesium ion binding
p53 binding
protein serine/threonine kinase activity
protein binding
ATP binding
LRR domain binding
protein kinase activator activity