Hs04594135_cn

• Gene Symbol: TANK
• Assay Reference Genome Location: Chr.2:161167310 on build GRCh38
• Cytoband: 2q24.2

Target Gene Details

• Entrez Gene ID: 10010
• Gene Name: TRAF family member associated NFKB activator
• Gene Aliases: I-TRAF, ITRAF, TRAF2
• Location: Chr.2:161136955-161236176 on Build GRCh38
• Assay Gene Location: Within Intron 5

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
TANK	NM_001199135.1			NP_001186064.1
	NM_004180.2			NP_004171.2
	NM_133484.1			NP_597841.1
	XM_005246207.3			XP_005246264.2
	XM_017003093.1			XP_016858582.1
	XM_017003094.1			XP_016858583.1
	XM_017003095.1			XP_016858584.1
	XM_017003096.1			XP_016858585.1
	XM_017003097.1			XP_016858586.1
	AK313096.1
	BC067779.1			AAH67779.1
	U59863.1			AAC50681.1
	U63830.1			AAC50770.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
dgv7140n54	Chr.2:161155624 - 161270523 on Build GRCh38	Loss	LOC101929512 LOC100996579 TANK
nsv834437	Chr.2:161075774 - 161268203 on Build GRCh38	Gain	LOC101929512 LOC100996579 TANK

More Information

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Gene Ontology Categories:

Process(es)

proteolysis
cellular response to DNA damage stimulus
signal transduction
I-kappaB kinase/NF-kappaB signaling
TRIF-dependent toll-like receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
cellular response to interleukin-1
cellular response to tumor necrosis factor
cellular response to ionizing radiation
positive regulation of protein deubiquitination
positive regulation of ubiquitin-specific protease activity

Function(s)

thiol-dependent ubiquitin-specific protease activity
protein binding
ubiquitin protein ligase binding
deubiquitinase activator activity
metal ion binding