Hs05033730_cn

• Gene Symbol: CYP7B1
• Assay Reference Genome Location: Chr.8:64609609 on build GRCh38
• Cytoband: 8q12.3

Target Gene Details

• Entrez Gene ID: 9420
• Gene Name: cytochrome P450 family 7 subfamily B member 1
• Gene Aliases: CBAS3, CP7B, SPG5A
• Location: Chr.8:64590851-64798791 on Build GRCh38
• Assay Gene Location: Within Intron 6

Gene Symbol	Transcript Accession	Exon Location	Assay Transcript Location	Protein ID
CYP7B1	NM_001324112.1			NP_001311041.1
	NM_004820.4			NP_004811.1
	XM_017014002.1			XP_016869491.1
	AF029403.1			AAC95426.1
	AF127090.1			AAD20021.1
	BC029155.1
	BC136574.1
	BM729103.1

Target Copy Number Variation Details

• DGV Version: Release date: 2016-05-15, GRCh GRCh38

Target Variation	Location	CNV Subtype	Genes
nsv611449	Chr.8:64598475 - 64630844 on Build GRCh38	Loss	CYP7B1

More Information

Additional Information:

For this assay, SNP(s) [rs148775285] are located under a primer or probe sequence. To help evaluate the possible impact of a given SNP on your experiment, please refer to the 1000 Genomes and NCBI dbSNP databases. A higher minor allele frequency in your study population represents a higher risk to assay performance.

• Set Membership: Intragenic, Intronic, Non-exonic, DGV Variation

Panther Classification:

Molecular Function -

oxygenase

Gene Ontology Categories:

Process(es)

bile acid biosynthetic process
cholesterol metabolic process
sterol metabolic process
negative regulation of intracellular estrogen receptor signaling pathway
B cell chemotaxis
positive regulation of epithelial cell proliferation
oxidation-reduction process
prostate gland epithelium morphogenesis

Function(s)

iron ion binding
oxysterol 7-alpha-hydroxylase activity
heme binding
25-hydroxycholesterol 7alpha-hydroxylase activity