103344

• Gene Symbol: CHEK2
• Gene Name: checkpoint kinase 2
• Gene Aliases: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
• Chromosome Location: Chr.22: 28687743 - 28741866 on Build GRCh38
• UniGene ID: Hs.291363
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CHEK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005735.1	NP_001005735.1	4	559
	NM_001257387.1	NP_001244316.1	3	430
	NM_007194.3	NP_009125.1	3	430
	NM_145862.2	NP_665861.1	3	430
	XM_011529839.2	XP_011528141.1	4	581
	XM_011529840.2	XP_011528142.1	4	583
	XM_011529841.1	XP_011528143.1	4	563
	XM_011529842.2	XP_011528144.1	3	451
	XM_011529843.1	XP_011528145.1	3	430
	XM_011529844.2	XP_011528146.1	4	591
	XM_011529845.2	XP_011528147.1	2	137
	XM_017028560.1	XP_016884049.1	4	545
GenBank mRNA	AB040105.1	-	2	358
	AF086904.1	-	2	358
	AF096279.1	-	2	358
	AF174135.1	-	2	358
	AF217975.1	-	3	1029
	AJ131197.1	-	2	358
	AJ783839.1	-	2	358
	AK289360.1	-	3	409
	AK290754.1	-	3	432
	AY551296.1	-	2	358
	AY551297.1	-	3	487
	AY551298.1	-	2	358
	AY551299.1	-	2	358
	AY551300.1	-	2	358
	AY551301.1	-	2	358
	AY551302.1	-	2	358
	AY551305.1	-	2	358
	BC004207.2	-	3	385	3532866
	BM838597.1	-	3	430
	CR456418.1	-	4	558

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
G2/M transition of mitotic cell cycle
replicative cell aging
positive regulation of protein phosphorylation
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
peptidyl-serine phosphorylation
cellular response to drug
regulation of protein catabolic process
signal transduction in response to DNA damage
cellular protein catabolic process
positive regulation of transcription, DNA-templated
protein autophosphorylation
protein stabilization
cell division
negative regulation of cell cycle arrest
signal transduction involved in intra-S DNA damage checkpoint
mitotic spindle assembly
replicative senescence
regulation of signal transduction by p53 class mediator
response to doxorubicin
cellular response to bisphenol A
negative regulation of DNA damage checkpoint
positive regulation of anoikis

Function(s)

protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding