104539

• Gene Symbol: PTPN2
• Gene Name: protein tyrosine phosphatase, non-receptor type 2
• Gene Aliases: PTN2, PTPT, TC-PTP, TCELLPTP, TCPTP
• Chromosome Location: Chr.18: 12785478 - 12884351 on Build GRCh38
• UniGene ID: Hs.654527
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PTPN2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001207013.1	NP_001193942.1	3, 4	463
	NM_001308287.1	NP_001295216.1	2, 3	358
	NM_002828.3	NP_002819.2	3, 4	463
	NM_080422.2	NP_536347.1	3, 4	463
	NM_080423.2	NP_536348.1	3, 4	463
	XM_005258124.3	XP_005258181.1	3, 4	461
	XM_005258125.3	XP_005258182.1	3, 4	461
	XM_011525705.2	XP_011524007.1	4, 5	681
	XM_011525706.2	XP_011524008.1	3, 4	386
	XM_017025884.1	XP_016881373.1	3, 4	479
	XM_017025885.1	XP_016881374.1	4, 5	665
	XM_017025886.1	XP_016881375.1	2, 3	353
	XM_017025887.1	XP_016881376.1	2, 3	304
	XM_017025888.1	XP_016881377.1	2, 3	304
GenBank mRNA	AB209569.1	-	2, 3	390
	AK225706.1	-	3, 4	342
	AK290649.1	-	3, 4	345
	AK292570.1	-	3, 4	363
	BC008244.1	-	3, 4	306	3872164
	BC016727.1	-	3, 4	375	4081330
	BG699440.1	-	3, 4	468
	M25393.1	-	3, 4	329

More Information

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

negative regulation of cell proliferation
insulin receptor signaling pathway
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of lipid storage
B cell differentiation
T cell differentiation
erythrocyte differentiation
peptidyl-tyrosine dephosphorylation
negative regulation of epidermal growth factor receptor signaling pathway
negative regulation of tyrosine phosphorylation of Stat1 protein
negative regulation of tyrosine phosphorylation of Stat5 protein
negative regulation of tyrosine phosphorylation of Stat6 protein
glucose homeostasis
negative regulation of macrophage differentiation
positive regulation of gluconeogenesis
negative regulation of insulin receptor signaling pathway
negative regulation of inflammatory response
negative regulation of T cell receptor signaling pathway
negative regulation of chemotaxis
regulation of interferon-gamma-mediated signaling pathway
negative regulation of interferon-gamma-mediated signaling pathway
negative regulation of type I interferon-mediated signaling pathway
negative regulation of protein tyrosine kinase activity
negative regulation of interleukin-6-mediated signaling pathway
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of interleukin-2-mediated signaling pathway
negative regulation of prolactin signaling pathway
negative regulation of interleukin-4-mediated signaling pathway
negative regulation of macrophage colony-stimulating factor signaling pathway
negative regulation of positive thymic T cell selection
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of PERK-mediated unfolded protein response
negative regulation of platelet-derived growth factor receptor-beta signaling pathway

Function(s)

protein tyrosine phosphatase activity
non-membrane spanning protein tyrosine phosphatase activity
integrin binding
protein binding
protein kinase binding
syntaxin binding
receptor tyrosine kinase binding