106120

• Gene Symbol: APP
• Gene Name: amyloid beta precursor protein
• Gene Aliases: AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
• Chromosome Location: Chr.21: 25880550 - 26171128 on Build GRCh38
• UniGene ID: Hs.434980
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: APP
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000484.3	NP_000475.1	12, 13	1795
	NM_001136016.3	NP_001129488.1	11, 12	1719
	NM_001136129.2	NP_001129601.1	9, 10	1402
	NM_001136130.2	NP_001129602.1	11, 12	1627
	NM_001136131.2	NP_001129603.1	10, 11	1457
	NM_001204301.1	NP_001191230.1	12, 13	1795
	NM_001204302.1	NP_001191231.1	11, 12	1738
	NM_001204303.1	NP_001191232.1	10, 11	1570
	NM_201413.2	NP_958816.1	11, 12	1738
	NM_201414.2	NP_958817.1	10, 11	1570
GenBank mRNA	A02759.1	-	10, 11	1516
	AF282245.1	-	9, 10	1329
	AK294534.1	-	11, 12	1574
	AK295373.1	-	2, 3	295
	AK295621.1	-	11, 12	1680
	AK296229.1	-	10, 11	1457
	AK297229.1	-	8, 9	933
	AK297412.1	-	9, 10	1299
	AK298861.1	-	9, 10	1472
	AK312326.1	-	12, 13	1660
	BC065529.1	-	11, 12	1669	6152423
	M16765.1	-	5, 6	530
	M18734.1	-	1, 2	78
	M28373.1	-	9, 10	1301
	X06989.1	-	11, 12	1662
	Y00264.1	-	10, 11	1517

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_019288, XM_006248010, XM_006248009, XM_006248011, XM_006248008, and others.
This siRNA also targets the following transcripts in Mouse: NM_001198826, NM_001198824, NM_001198823, NM_001198825, NM_007471, and others.

Panther Classification:

Molecular Function -

protease inhibitor

Gene Ontology Categories:

Process(es)

response to yeast
suckling behavior
platelet degranulation
mRNA polyadenylation
regulation of translation
protein phosphorylation
cellular copper ion homeostasis
endocytosis
response to oxidative stress
cell adhesion
regulation of epidermal growth factor-activated receptor activity
Notch signaling pathway
axonogenesis
mating behavior
locomotory behavior
axo-dendritic transport
cholesterol metabolic process
adult locomotory behavior
visual learning
cellular process
response to lead ion
negative regulation of endopeptidase activity
positive regulation of peptidase activity
positive regulation of G2/M transition of mitotic cell cycle
axon midline choice point recognition
neuron remodeling
dendrite development
antibacterial humoral response
antifungal humoral response
extracellular matrix organization
forebrain development
neuron projection development
ionotropic glutamate receptor signaling pathway
regulation of multicellular organism growth
regulation of protein binding
cellular protein metabolic process
innate immune response
negative regulation of neuron differentiation
positive regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
collateral sprouting in absence of injury
regulation of synapse structure or activity
defense response to Gram-negative bacterium
defense response to Gram-positive bacterium
neuromuscular process controlling balance
synaptic growth at neuromuscular junction
neuron apoptotic process
smooth endoplasmic reticulum calcium ion homeostasis
cellular response to cAMP
cellular response to norepinephrine stimulus
amyloid fibril formation
cellular response to nerve growth factor stimulus

Function(s)

DNA binding
serine-type endopeptidase inhibitor activity
receptor binding
protein binding
heparin binding
peptidase activator activity
enzyme binding
identical protein binding
transition metal ion binding
PTB domain binding
growth factor receptor binding