107927 Validated

• Gene Symbol: HDAC4
• Gene Name: histone deacetylase 4
• Gene Aliases: AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA
• Chromosome Location: Chr.2: 239048168 - 239401647 on Build GRCh38
• UniGene ID: Hs.20516
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HDAC4
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_006037.3	NP_006028.2	27	5363
	XM_006712877.3	XP_006712940.1	26	11309
	XM_006712878.3	XP_006712941.1	27	4883
	XM_006712879.3	XP_006712942.1	26	10776
	XM_006712880.3	XP_006712943.1	26	10788
	XM_011512217.2	XP_011510519.1	26	11324
	XM_011512218.2	XP_011510520.1	26	11309
	XM_011512219.2	XP_011510521.1	26	11294
	XM_011512220.2	XP_011510522.1	26	5063
	XM_011512221.1	XP_011510523.1	27	5051
	XM_011512222.2	XP_011510524.1	27	5352
	XM_011512223.2	XP_011510525.1	27	4866
	XM_011512224.2	XP_011510526.1	26	5254
	XM_011512225.2	XP_011510527.1	26	5239
	XM_011512226.2	XP_011510528.1	26	4811
	XM_011512227.2	XP_011510529.1	25	10338
	XM_011512230.1	XP_011510532.1	21	4249
	XM_017005394.1	XP_016860883.1	25	11193
	XM_017005395.1	XP_016860884.1	23	4115
GenBank mRNA	AB006626.2	-	27	5364

More Information

Matching Taqman Gene Expression Assay:

Hs00195814_m1

Panther Classification:

Molecular Function -

histone modifying enzyme

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
skeletal system development
osteoblast development
chromatin remodeling
transcription, DNA-templated
inflammatory response
nervous system development
positive regulation of cell proliferation
negative regulation of cell proliferation
positive regulation of lamellipodium assembly
negative regulation of myotube differentiation
regulation of cardiac muscle contraction by calcium ion signaling
response to denervation involved in regulation of muscle adaptation
cardiac muscle hypertrophy in response to stress
positive regulation of smooth muscle cell migration
chromatin modification
histone deacetylation
B cell differentiation
positive regulation of protein sumoylation
peptidyl-lysine deacetylation
regulation of gene expression, epigenetic
B cell activation
response to drug
regulation of protein binding
negative regulation of sequence-specific DNA binding transcription factor activity
positive regulation of neuron apoptotic process
negative regulation of osteoblast differentiation
negative regulation of glycolytic process
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of smooth muscle cell proliferation
regulation of skeletal muscle fiber development
positive regulation of sequence-specific DNA binding transcription factor activity
response to interleukin-1
histone H3 deacetylation
histone H4 deacetylation
cellular response to mechanical stimulus
cellular response to tumor necrosis factor
cellular response to parathyroid hormone stimulus
positive regulation of reactive oxygen species biosynthetic process

Function(s)

RNA polymerase III transcription factor binding
core promoter binding
chromatin binding
transcription corepressor activity
histone deacetylase activity
protein binding
transcription factor binding
zinc ion binding
protein kinase binding
potassium ion binding
NAD-dependent histone deacetylase activity (H3-K14 specific)
protein deacetylase activity
activating transcription factor binding
histone deacetylase binding
sequence-specific DNA binding
transcription regulatory region DNA binding
repressing transcription factor binding