108387

• Gene Symbol: PPARGC1A
• Gene Name: PPARG coactivator 1 alpha
• Gene Aliases: LEM6, PGC-1(alpha), PGC-1alpha, PGC-1v, PGC1, PGC1A, PPARGC1
• Chromosome Location: Chr.4: 23792021 - 24472975 on Build GRCh38
• UniGene ID: Hs.527078
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PPARGC1A
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_013261.3	NP_037393.1	13	3751
	XM_005248131.4	XP_005248188.1	13	4494
	XM_005248132.1	XP_005248189.1	13	3673
	XM_005248134.4	XP_005248191.1	11	3466
	XM_011513765.2	XP_011512067.1	14	4243
	XM_011513766.1	XP_011512068.1	14	3825
	XM_011513767.2	XP_011512069.1	14	5963
	XM_011513768.1	XP_011512070.1	13	3724
	XM_011513770.2	XP_011512072.1	12	3961
	XM_011513771.1	XP_011512073.1	12	3570
	XM_017007664.1	XP_016863153.1	15	4200
GenBank mRNA	AF106698.1	-	13	3739

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008770220, XM_008770219.
This siRNA also targets the following transcripts in Mouse: NM_008904, AK082685, AK043827, AK032149.

Panther Classification:

Molecular Function -

transcription cofactor

Gene Ontology Categories:

Process(es)

response to reactive oxygen species
mitophagy
temperature homeostasis
cellular glucose homeostasis
negative regulation of protein phosphorylation
response to dietary excess
response to ischemia
galactose metabolic process
gluconeogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
mRNA processing
protein complex assembly
mitochondrion organization
positive regulation of transcription from RNA polymerase II promoter by pheromones
aging
digestion
circadian rhythm
androgen metabolic process
RNA splicing
response to cold
positive regulation of mitochondrion organization
skeletal muscle atrophy
response to muscle activity
response to electrical stimulus involved in regulation of muscle adaptation
negative regulation of smooth muscle cell migration
fatty acid oxidation
cerebellum development
respiratory electron transport chain
androgen receptor signaling pathway
forebrain development
circadian regulation of gene expression
cellular response to oxidative stress
positive regulation of histone acetylation
cellular response to potassium ion
response to statin
response to drug
response to starvation
regulation of circadian rhythm
response to leucine
negative regulation of neuron apoptotic process
cellular respiration
positive regulation of gluconeogenesis
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
positive regulation of smooth muscle cell proliferation
negative regulation of smooth muscle cell proliferation
protein stabilization
brown fat cell differentiation
positive regulation of sequence-specific DNA binding transcription factor activity
flavone metabolic process
adipose tissue development
cellular response to lipopolysaccharide
cellular response to nitrite
cellular response to caffeine
cellular response to fructose stimulus
cellular response to glucose stimulus
cellular response to interleukin-6
cellular response to tumor necrosis factor
cellular response to follicle-stimulating hormone stimulus
cellular response to estradiol stimulus
cellular response to hypoxia
cellular response to transforming growth factor beta stimulus
response to epinephrine
response to norepinephrine
negative regulation of mitochondrial fission
cellular response to thyroid hormone stimulus
negative regulation of neuron death
response to metformin
positive regulation of cellular respiration
positive regulation of mitochondrial DNA metabolic process
positive regulation of muscle tissue development
positive regulation of glomerular visceral epithelial cell apoptotic process
cellular response to ionomycin
cellular response to resveratrol
response to methionine
adaptive thermogenesis
positive regulation of progesterone biosynthetic process
negative regulation of receptor activity
regulation of N-methyl-D-aspartate selective glutamate receptor activity
positive regulation of energy homeostasis
positive regulation of ATP biosynthetic process

Function(s)

nucleotide binding
RNA polymerase II transcription cofactor activity
DNA binding
transcription coactivator activity
RNA binding
protein binding
transcription factor binding
ligand-dependent nuclear receptor binding
estrogen receptor binding
ligand-dependent nuclear receptor transcription coactivator activity
chromatin DNA binding
ubiquitin protein ligase binding
peroxisome proliferator activated receptor binding
alpha-tubulin binding
sequence-specific DNA binding
androgen receptor binding
promoter-specific chromatin binding