117920

• Gene Symbol: POLE
• Gene Name: DNA polymerase epsilon, catalytic subunit
• Gene Aliases: CRCS12, FILS, POLE1
• Chromosome Location: Chr.12: 132623762 - 132687524 on Build GRCh38
• UniGene ID: Hs.524871
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: POLE
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_006231.3	NP_006222.2	7	837
	XM_011534795.2	XP_011533097.1	7	832
	XM_011534799.2	XP_011533101.1	7	832
	XM_011534800.2	XP_011533102.1	7	832
GenBank mRNA	BC144561.1	-	7	660
	L09561.1	-	7	672
	S60080.1	-	6	560
	U49356.1	-	7	628

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001107152, XM_006249562, XM_008769335.
This siRNA also targets the following transcripts in Mouse: NM_011132, BC063246, AK141674, AF123502, BC048166.

Panther Classification:

Molecular Function -

DNA metabolism protein

Gene Ontology Categories:

Process(es)

G1/S transition of mitotic cell cycle
telomere maintenance via recombination
DNA synthesis involved in DNA repair
DNA replication
DNA replication initiation
base-excision repair, gap-filling
nucleotide-excision repair, DNA gap filling
embryonic organ development
nucleic acid phosphodiester bond hydrolysis

Function(s)

nucleotide binding
DNA binding
chromatin binding
DNA-directed DNA polymerase activity
zinc ion binding
3'-5' exonuclease activity
4 iron, 4 sulfur cluster binding