122297

• Gene Symbol: MDM2
• Gene Name: MDM2 proto-oncogene
• Gene Aliases: ACTFS, HDMX, hdm2
• Chromosome Location: Chr.12: 68808149 - 68845544 on Build GRCh38
• UniGene ID: Hs.484551
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: MDM2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001145337.2	NP_001138809.1	4	275
	NM_001145339.2	NP_001138811.1	4	525
	NM_002392.5	NP_002383.2	4	525
	XM_005268872.4	XP_005268929.1	4	453
	XM_006719399.3	XP_006719462.1	2	108
GenBank mRNA	AF092843.1	-	4	233
	AF092844.1	-	4	233
	AF385323.1	-	3	201
	AJ430612.1	-	3	201
	AJ430614.1	-	3	201
	AJ491698.1	-	3	201
	AJ491699.1	-	4	288
	AJ491700.1	-	3	201
	AK290341.1	-	4	475
	AM902642.1	-	4	294
	AM902646.1	-	3	201
	AM902647.1	-	4	288
	AM902650.1	-	3	201
	AM902651.1	-	3	201
	AM902654.1	-	3	201
	AM902655.1	-	3	201
	AM902658.1	-	4	288
	AM902659.1	-	3	201
	AM902660.1	-	3	201
	AM902666.1	-	3	201
	AM902667.1	-	3	201
	AM902668.1	-	3	201
	AM902669.1	-	3	201
	AM902670.1	-	2	126
	AM902672.1	-	3	201
	AM902678.1	-	3, 4	201
	AM902680.1	-	3	201
	AM902681.1	-	3	201
	BC152384.1	-	3	204
	BC152390.1	-	3	204
	BE296905.1	-	4	490
	BT007258.1	-	3	201
	EU076747.1	-	4	275
	EU076749.1	-	4	275
	GQ848196.1	-	2	126
	HM213901.1	-	3	201
	JX015379.1	-	3	201
	JX015390.1	-	3	201
	JX015391.1	-	3	201
	JX015392.1	-	3	201
	M92424.1	-	4	512
	U33203.1	-	3	201
	Z12020.1	-	4	512

More Information

Panther Classification:

Molecular Function -

chromatin/chromatin-binding, or -regulatory protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
blood vessel development
blood vessel remodeling
regulation of heart rate
atrioventricular valve morphogenesis
endocardial cushion morphogenesis
ventricular septum development
atrial septum development
protein complex assembly
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
traversing start control point of mitotic cell cycle
positive regulation of cell proliferation
response to toxic substance
response to carbohydrate
response to iron ion
positive regulation of gene expression
negative regulation of protein processing
viral process
protein ubiquitination
protein sumoylation
peptidyl-lysine modification
protein destabilization
response to magnesium ion
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
protein localization to nucleus
regulation of protein catabolic process
response to cocaine
response to drug
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
response to morphine
negative regulation of DNA damage response, signal transduction by p53 class mediator
establishment of protein localization
response to ether
negative regulation of transcription, DNA-templated
positive regulation of mitotic cell cycle
response to antibiotic
positive regulation of protein export from nucleus
response to steroid hormone
cardiac septum morphogenesis
cellular response to hydrogen peroxide
negative regulation of cell cycle arrest
cellular response to antibiotic
cellular response to vitamin B1
cellular response to alkaloid
cellular response to growth factor stimulus
cellular response to peptide hormone stimulus
cellular response to estrogen stimulus
cellular response to hypoxia
cellular response to UV-C
regulation of signal transduction by p53 class mediator
negative regulation of signal transduction by p53 class mediator

Function(s)

p53 binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
ligase activity
SUMO transferase activity
enzyme binding
ubiquitin protein ligase binding
identical protein binding
peroxisome proliferator activated receptor binding
ubiquitin protein ligase activity
scaffold protein binding