144230

• Gene Symbol: PDE4D
• Gene Name: phosphodiesterase 4D
• Gene Aliases: ACRDYS2, DPDE3, HSPDE4D, PDE43, PDE4DN2, STRK1
• Chromosome Location: Chr.5: 58969038 - 60488098 on Build GRCh38
• UniGene ID: Hs.117545
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PDE4D
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001104631.1	NP_001098101.1	2	770
	NM_001165899.1	NP_001159371.1	4	661
	NM_001197218.1	NP_001184147.1	2	509
	NM_001197219.1	NP_001184148.1	2	287
	NM_001197220.1	NP_001184149.1	2	925
	NM_006203.4	NP_006194.2	2	313
	XM_005248537.3	XP_005248594.1	2	1467
	XM_005248538.4	XP_005248595.1	3	3368
	XM_011543469.1	XP_011541771.1	5	750
	XM_011543470.2	XP_011541772.1	5	674
	XM_011543471.1	XP_011541773.1	4	627
	XM_011543473.1	XP_011541775.1	4	575
	XM_011543477.2	XP_011541779.1	4	577
	XM_017009565.1	XP_016865054.1	5	787
	XM_017009566.1	XP_016865055.1	5	677
	XM_017009567.1	XP_016865056.1	3	415
	XM_017009568.1	XP_016865057.1	5	661
	XM_017009569.1	XP_016865058.1	4	540
	XM_017009570.1	XP_016865059.1	2	1434
	XM_017009571.1	XP_016865060.1	5	657
GenBank mRNA	AF012073.1	-	2	523
	AF536976.1	-	3	484
	AF536977.1	-	2	287
	AJ250854.1	-	2	406
	AJ250855.1	-	2	261
	AY245866.1	-	4	626
	AY245867.1	-	2	925
	AY388960.1	-	2	208
	BC008390.1	-	2	533
	BT007398.1	-	2	406
	L20970.1	-	2	321
	U02882.1	-	1	91
	U50159.1	-	2	264

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001113328, NM_001113329, NM_001113334, NM_017032, NM_001113332, and others.

Panther Classification:

Molecular Function -

phosphodiesterase

Gene Ontology Categories:

Process(es)

regulation of heart rate
cAMP catabolic process
smooth muscle contraction
aging
regulation of receptor activity
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
cAMP-mediated signaling
neutrophil chemotaxis
regulation of cAMP metabolic process
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
positive regulation of interleukin-5 production
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
negative regulation of heart contraction
T cell receptor signaling pathway
regulation of ryanodine-sensitive calcium-release channel activity
establishment of endothelial barrier
cellular response to lipopolysaccharide
cellular response to epinephrine stimulus
adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
adrenergic receptor signaling pathway involved in positive regulation of heart rate
regulation of cell communication by electrical coupling involved in cardiac conduction
negative regulation of relaxation of cardiac muscle

Function(s)

3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
protein binding
drug binding
enzyme binding
cAMP binding
beta-2 adrenergic receptor binding
ion channel binding
metal ion binding
ATPase binding
scaffold protein binding