174323

• Gene Symbol: Ern1
• Gene Name: endoplasmic reticulum (ER) to nucleus signalling 1
• Gene Aliases: 9030414B18Rik, AI225830, C85377, Ire1a, Ire1alpha, Ire1p
• Chromosome Location: Chr.11: 106397620 - 106487796 on Build GRCm38
• UniGene ID: Mm.340943
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ern1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_023913.2	NP_076402.1	14	1874
GenBank mRNA	AB031332.1	-	14	1874
	AK077041.1	-		1896
	AK080709.1	-	8	1127

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001191926, XM_006247634, XM_006247633.

Panther Classification:

Molecular Function -

endoribonuclease

Gene Ontology Categories:

Process(es)

endothelial cell proliferation
transcription, DNA-templated
regulation of transcription, DNA-templated
mRNA cleavage
mRNA processing
protein phosphorylation
apoptotic process
response to unfolded protein
activation of signaling protein activity involved in unfolded protein response
cell cycle arrest
activation of JUN kinase activity
metabolic process
phosphorylation
endoplasmic reticulum unfolded protein response
mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response
positive regulation of RNA splicing
response to endoplasmic reticulum stress
cellular response to vascular endothelial growth factor stimulus
peptidyl-serine autophosphorylation
IRE1-mediated unfolded protein response
protein autophosphorylation
mRNA splicing, via endonucleolytic cleavage and ligation
mRNA endonucleolytic cleavage involved in unfolded protein response
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
cellular response to glucose stimulus
RNA phosphodiester bond hydrolysis, endonucleolytic
positive regulation of endoplasmic reticulum unfolded protein response
insulin metabolic process
peptidyl-serine trans-autophosphorylation

Function(s)

nucleotide binding
magnesium ion binding
catalytic activity
endonuclease activity
endoribonuclease activity
ribonuclease activity
protein kinase activity
protein serine/threonine kinase activity
protein binding
ATP binding
kinase activity
bidentate ribonuclease III activity
transferase activity
transferase activity, transferring phosphorus-containing groups
hydrolase activity
enzyme binding
Hsp70 protein binding
identical protein binding
protein homodimerization activity
ADP binding
metal ion binding
Hsp90 protein binding