198513

• Gene Symbol: Gclm
• Gene Name: glutamate cysteine ligase, modifier subunit
• Gene Aliases: Glclr
• Chromosome Location: Chr.2: 225827504 - 225847876 on Build Rnor_6.0
• UniGene ID: Rn.2460
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Gclm
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_017305.2	NP_059001.1	5	562
GenBank mRNA	BC078867.1	-	5	562	7110139
	DQ266366.1	-	4	304
	L22191.1	-	5	500
	S65555.1	-	5	500

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: NM_002061, CR541833, BC041809, L35546, AK290449, and others.
This siRNA also targets the following transcripts in Mouse: NM_008129, AK172387, BC138783, CT010256, AK028236, and others.

Panther Classification:

Molecular Function -

ligase, metabolite interconversion enzyme

Gene Ontology Categories:

Process(es)

cysteine metabolic process
glutamate metabolic process
glutathione metabolic process
glutathione biosynthetic process
response to oxidative stress
apoptotic mitochondrial changes
positive regulation of glutamate-cysteine ligase activity
response to drug
negative regulation of neuron apoptotic process
regulation of blood vessel size
response to nitrosative stress
regulation of mitochondrial depolarization
negative regulation of extrinsic apoptotic signaling pathway

Function(s)

glutamate-cysteine ligase activity
enzyme regulator activity
glutamate-cysteine ligase catalytic subunit binding
protein heterodimerization activity