222

• Gene Symbol: KDR
• Gene Name: kinase insert domain receptor
• Gene Aliases: CD309, FLK1, VEGFR, VEGFR2
• Chromosome Location: Chr.4: 55078259 - 55125595 on Build GRCh38
• UniGene ID: Hs.479756
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: KDR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_002253.2	NP_002244.1	11, 12	1835
GenBank mRNA	AB209901.1	-	11, 12	1820
	AF035121.1	-	11, 12	1836
	AF063658.1	-	11, 12	1533
	BC131822.1	-	11, 12	1595	40129287
	EU826563.1	-	11, 12	1533
	FJ899739.1	-	11, 12	1533
	L04947.1	-	11, 12	1527
	X61656.1	-	11, 12	1527

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_013062, BC087029, U93307, U93306.
This siRNA also targets the following transcripts in Mouse: NM_010612, X70842, BC020530, EU884114, X59397, and others.

Panther Classification:

Molecular Function -

transmembrane signal receptor

Gene Ontology Categories:

Process(es)

angiogenesis
vasculogenesis
positive regulation of protein phosphorylation
positive regulation of endothelial cell proliferation
cell migration involved in sprouting angiogenesis
endothelium development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell proliferation
regulation of cell shape
positive regulation of endothelial cell migration
positive regulation of phosphatidylinositol 3-kinase signaling
viral process
positive regulation of macroautophagy
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
extracellular matrix organization
positive regulation of cell migration
embryonic hemopoiesis
calcium-mediated signaling using intracellular calcium source
cellular response to vascular endothelial growth factor stimulus
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
peptidyl-tyrosine autophosphorylation
negative regulation of apoptotic process
positive regulation of MAPK cascade
positive regulation of angiogenesis
protein autophosphorylation
vascular endothelial growth factor receptor signaling pathway
positive regulation of positive chemotaxis
positive regulation of nitric-oxide synthase biosynthetic process
positive regulation of focal adhesion assembly
positive regulation of mitochondrial depolarization
positive regulation of ERK1 and ERK2 cascade
positive regulation of mitochondrial fission
negative regulation of endothelial cell apoptotic process
positive regulation of vasculogenesis

Function(s)

protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
vascular endothelial growth factor-activated receptor activity
integrin binding
protein binding
ATP binding
growth factor binding
Hsp90 protein binding