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• Gene Symbol: LYN
• Gene Name: LYN proto-oncogene, Src family tyrosine kinase
• Gene Aliases: JTK8, p53Lyn, p56Lyn
• Chromosome Location: Chr.8: 55877305 - 56012447 on Build GRCh38
• UniGene ID: Hs.491767
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: LYN
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001111097.2	NP_001104567.1	3, 4	391
	NM_002350.3	NP_002341.1	3, 4	454
	XM_011517529.2	XP_011515831.1	2, 3	2839
	XM_017013415.1	XP_016868904.1	2, 3	2839
	XM_017013416.1	XP_016868905.1	3, 4	130
GenBank mRNA	AK290494.1	-	3, 4	364
	AK298677.1	-	1, 2	42
	BC059394.1	-	3, 4	383
	BC068551.1	-	3, 4	383
	BC075001.2	-	2, 3	197	30915399
	BC075002.2	-	2, 3	197	30915611
	BC126456.1	-	4, 5	291	8992172
	BC126458.1	-	4, 5	338	8992174
	CB990993.1	-	3, 4	416
	M16038.1	-	3, 4	469
	M79321.1	-	2, 3	133

More Information

Gene Ontology Categories:

Process(es)

B cell homeostasis
regulation of cytokine production
regulation of protein phosphorylation
negative regulation of protein phosphorylation
stimulatory C-type lectin receptor signaling pathway
adaptive immune response
Fc receptor mediated stimulatory signaling pathway
tolerance induction to self antigen
histamine secretion by mast cell
platelet degranulation
negative regulation of myeloid leukocyte differentiation
immune response-regulating cell surface receptor signaling pathway
Fc receptor mediated inhibitory signaling pathway
regulation of B cell apoptotic process
protein phosphorylation
inflammatory response
cellular response to DNA damage stimulus
response to sterol depletion
signal transduction
transmembrane receptor protein tyrosine kinase signaling pathway
central nervous system development
blood coagulation
positive regulation of cell proliferation
negative regulation of cell proliferation
response to toxic substance
response to hormone
response to carbohydrate
positive regulation of neuron projection development
oligodendrocyte development
response to organic cyclic compound
viral process
peptidyl-tyrosine phosphorylation
signal transduction by protein phosphorylation
platelet activation
erythrocyte differentiation
positive regulation of cell migration
negative regulation of B cell proliferation
neuron projection development
T cell costimulation
lipopolysaccharide-mediated signaling pathway
cellular response to extracellular stimulus
response to insulin
regulation of mast cell activation
regulation of cell adhesion mediated by integrin
negative regulation of toll-like receptor 2 signaling pathway
negative regulation of toll-like receptor 4 signaling pathway
cellular response to heat
peptidyl-tyrosine autophosphorylation
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
response to drug
positive regulation of tyrosine phosphorylation of STAT protein
response to amino acid
regulation of mast cell degranulation
negative regulation of MAP kinase activity
positive regulation of phosphatidylinositol 3-kinase activity
innate immune response
regulation of erythrocyte differentiation
protein autophosphorylation
ephrin receptor signaling pathway
response to axon injury
cytokine secretion
regulation of cytokine secretion
regulation of inflammatory response
negative regulation of immune response
B cell receptor signaling pathway
regulation of B cell receptor signaling pathway
positive regulation of B cell receptor signaling pathway
leukocyte migration
positive regulation of cellular component movement
regulation of release of sequestered calcium ion into cytosol
positive regulation of glial cell proliferation
positive regulation of Fc receptor mediated stimulatory signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
positive regulation of stress-activated protein kinase signaling cascade
regulation of ERK1 and ERK2 cascade
negative regulation of ERK1 and ERK2 cascade
positive regulation of oligodendrocyte progenitor proliferation
negative regulation of mast cell proliferation
positive regulation of mast cell proliferation
cellular response to retinoic acid
regulation of monocyte chemotaxis
regulation of platelet aggregation
dendritic cell differentiation
negative regulation of intracellular signal transduction
positive regulation of dendritic cell apoptotic process

Function(s)

protein tyrosine kinase activity
non-membrane spanning protein tyrosine kinase activity
receptor signaling protein tyrosine kinase activity
receptor binding
platelet-derived growth factor receptor binding
integrin binding
protein binding
ATP binding
SH3 domain binding
ubiquitin protein ligase binding
gamma-tubulin binding
glycosphingolipid binding
ion channel binding
phosphoprotein binding