272488

• Gene Symbol: RAPGEF2
• Gene Name: Rap guanine nucleotide exchange factor 2
• Gene Aliases: CNrasGEF, NRAPGEP, PDZ-GEF1, PDZGEF1, RA-GEF, RA-GEF-1, Rap-GEP, nRap GEP
• Chromosome Location: Chr.4: 159104067 - 159360164 on Build GRCh38
• UniGene ID: Hs.744884
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: RAPGEF2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_014247.2	NP_055062.1	10	1653
	XM_005263358.3	XP_005263415.1	16	1920
	XM_005263359.3	XP_005263416.1	16	1922
	XM_005263360.3	XP_005263417.1	16	1914
	XM_005263361.3	XP_005263418.1	15	1902
	XM_006714420.3	XP_006714483.1	15	1902
	XM_006714421.3	XP_006714484.1	16	1887
	XM_006714422.3	XP_006714485.1	13	2135
	XM_011532425.2	XP_011530727.1	12	1750
	XM_011532426.2	XP_011530728.1	13	2687
	XM_011532427.2	XP_011530729.1	10	2337
	XM_017008856.1	XP_016864345.1	16	1921
	XM_017008857.1	XP_016864346.1	13	2686
	XM_017008858.1	XP_016864347.1	13	1654
	XM_017008859.1	XP_016864348.1	10	2337
GenBank mRNA	AB002311.1	-	10	1405
	AK294459.1	-	10	1654
	BC117321.1	-	10	1331	40125872

More Information

Panther Classification:

Molecular Function -

guanyl-nucleotide exchange factor

Gene Ontology Categories:

Process(es)

MAPK cascade
blood vessel development
neuron migration
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
small GTPase mediated signal transduction
negative regulation of cell proliferation
positive regulation of neuron projection development
cAMP-mediated signaling
ventricular system development
forebrain neuron development
microvillus assembly
neuron projection development
brain-derived neurotrophic factor receptor signaling pathway
positive regulation of protein binding
Rap protein signal transduction
intracellular signal transduction
nerve growth factor signaling pathway
positive regulation of GTPase activity
positive regulation of cAMP-mediated signaling
positive regulation of protein kinase activity
negative regulation of melanin biosynthetic process
regulation of synaptic plasticity
negative regulation of dendrite morphogenesis
establishment of endothelial barrier
positive regulation of ERK1 and ERK2 cascade
cellular response to cAMP
cellular response to cGMP
adenylate cyclase-activating adrenergic receptor signaling pathway
protein localization to plasma membrane
establishment of endothelial intestinal barrier
regulation of cell junction assembly
cellular response to nerve growth factor stimulus
positive regulation of cAMP-dependent protein kinase activity
positive regulation of dendritic cell apoptotic process
positive regulation of vasculogenesis
positive regulation of neuron migration

Function(s)

signal transducer activity
Ras guanyl-nucleotide exchange factor activity
GTPase activator activity
calcium ion binding
protein binding
Rap guanyl-nucleotide exchange factor activity
diacylglycerol binding
PDZ domain binding
cAMP binding
cGMP binding
beta-1 adrenergic receptor binding
WW domain binding
phosphatidic acid binding