4013

• Gene Symbol: HNF4A
• Gene Name: hepatocyte nuclear factor 4 alpha
• Gene Aliases: FRTS4, HNF4, HNF4a7, HNF4a8, HNF4a9, HNF4alpha, MODY, MODY1, NR2A1, NR2A21, TCF, TCF14
• Chromosome Location: Chr.20: 44355801 - 44432845 on Build GRCh38
• UniGene ID: Hs.116462
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: HNF4A
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000457.4	NP_000448.3	3	472
	NM_001030003.2	NP_001025174.1	3	293
	NM_001030004.2	NP_001025175.1	3	293
	NM_001258355.1	NP_001245284.1	4	563
	NM_001287182.1	NP_001274111.1	4	515
	NM_001287183.1	NP_001274112.1	4	515
	NM_001287184.1	NP_001274113.1	4	515
	NM_175914.4	NP_787110.2	3	293
	NM_178849.2	NP_849180.1	3	472
	NM_178850.2	NP_849181.1	3	472
	XM_005260407.3	XP_005260464.1	4	592
GenBank mRNA	AB307703.1	-	3	328
	AY680696.1	-	3	293
	AY680697.1	-	3	293
	AY680698.1	-	3	293
	BC137539.1	-	3	394	9021539
	BC137540.1	-	3	394	9021540
	BP274413.1	-	3	472
	FJ608822.1	-	4	511
	HQ692860.1	-	3	355
	HQ692868.1	-	3	289
	HQ692869.1	-	3	355
	X76930.1	-	3	347
	X87870.1	-	3	427
	X87871.1	-	3	412
	X87872.1	-	3	448
	Z49825.1	-	4	548

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: AF015275.

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor

Gene Ontology Categories:

Process(es)

regulation of transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
ornithine metabolic process
lipid metabolic process
acyl-CoA metabolic process
xenobiotic metabolic process
establishment of tissue polarity
sex differentiation
blood coagulation
negative regulation of cell proliferation
response to glucose
regulation of gastrulation
regulation of lipid metabolic process
signal transduction involved in regulation of gene expression
cell differentiation
negative regulation of cell growth
intracellular receptor signaling pathway
regulation of microvillus assembly
negative regulation of protein import into nucleus, translocation
response to drug
negative regulation of tyrosine phosphorylation of Stat5 protein
glucose homeostasis
steroid hormone mediated signaling pathway
negative regulation of sequence-specific DNA binding transcription factor activity
cell-cell junction organization
positive regulation of gluconeogenesis
positive regulation of fatty acid biosynthetic process
positive regulation of transcription, DNA-templated
negative regulation of mitotic cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of insulin secretion
response to cAMP
lipid homeostasis
phospholipid homeostasis
SMAD protein signal transduction
triglyceride homeostasis
negative regulation of activation of JAK2 kinase activity
positive regulation of cholesterol homeostasis

Function(s)

fatty-acyl-CoA binding
RNA polymerase II core promoter sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II activating transcription factor binding
DNA binding
transcription factor activity, sequence-specific DNA binding
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
receptor binding
fatty acid binding
protein binding
zinc ion binding
palmitoyl-CoA hydrolase activity
protein homodimerization activity
transcription regulatory region DNA binding