46874

• Gene Symbol: Dnmt1
• Gene Name: DNA (cytosine-5-)-methyltransferase 1
• Gene Aliases: -
• Chromosome Location: Chr.8: 21922515 - 21968495 on Build Rnor_6.0
• UniGene ID: Rn.6955
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Dnmt1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_053354.3	NP_445806.3	2	176
GenBank mRNA	AB012214.1	-	2	160
	AF116344.1	-	2	214
	D64060.1	-	2	48
	DV214494.1	-	2	142

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001199431, NM_010066, NM_001199433, NM_001199432, AF036009, and others.

Panther Classification:

Molecular Function -

DNA metabolism protein, DNA methyltransferase, nucleic acid metabolism protein

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
DNA methylation
transcription, DNA-templated
regulation of transcription, DNA-templated
brain development
aging
response to heat
response to toxic substance
response to organic substance
response to ionizing radiation
maintenance of DNA methylation
response to lead ion
DNA methylation on cytosine within a CG sequence
regulation of gene expression
positive regulation of gene expression
response to activity
gene silencing
chromatin modification
neuron differentiation
response to caffeine
response to nutrient levels
response to estradiol
response to lipopolysaccharide
DNA methylation on cytosine
response to vitamin A
response to testosterone
cellular response to platelet-derived growth factor stimulus
response to antidepressant
regulation of cell proliferation
response to drug
DNA hypermethylation
response to ethanol
negative regulation of transcription, DNA-templated
S-adenosylhomocysteine metabolic process
S-adenosylmethioninamine metabolic process
S-adenosylmethionine metabolic process
positive regulation of histone H3-K4 methylation
negative regulation of histone H3-K9 methylation
cellular response to amino acid stimulus
cellular response to lead ion
cellular response to transforming growth factor beta stimulus
C-5 methylation of cytosine
cellular response to nerve growth factor stimulus

Function(s)

DNA binding
chromatin binding
double-stranded DNA binding
RNA binding
DNA (cytosine-5-)-methyltransferase activity
protein binding
transcription factor binding
methyltransferase activity
zinc ion binding
methyl-CpG binding
S-adenosylmethionine-dependent methyltransferase activity
DNA-methyltransferase activity
protein domain specific binding
estrogen receptor binding
histone deacetylase binding
unmethylated CpG binding
DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates