501103

• Gene Symbol: Itch
• Gene Name: itchy, E3 ubiquitin protein ligase
• Gene Aliases: 6720481N21Rik, 8030492O04Rik, A130065M08, AIP4, C230047C07Rik
• Chromosome Location: Chr.2: 155133379 - 155226855 on Build GRCm38
• UniGene ID: Mm.208286
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Itch
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001243712.1	NP_001230641.1	11	1310
	NM_008395.3	NP_032421.2	10	1108
GenBank mRNA	AF037454.1	-	10	1024
	AK037940.1	-	10	1058
	AK048303.1	-	10	1029
	AK220164.1	-	11	1232
	BC062934.1	-	10	1057	30535756
	BC064678.1	-	10	1025	6409535

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: XM_008762337, XM_008762335, XM_008762336.

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

protein polyubiquitination
immune system process
positive regulation of T cell anergy
ubiquitin-dependent protein catabolic process
apoptotic process
protein ubiquitination
negative regulation of NF-kappaB transcription factor activity
protein K29-linked ubiquitination
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
negative regulation of apoptotic process
innate immune response
positive regulation of protein catabolic process
negative regulation of JNK cascade
negative regulation of alpha-beta T cell proliferation
negative regulation of defense response to virus
defense response to virus
protein K63-linked ubiquitination
protein K48-linked ubiquitination
regulation of protein deubiquitination

Function(s)

ubiquitin-protein transferase activity
protein binding
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
ribonucleoprotein complex binding
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
CXCR chemokine receptor binding
ubiquitin protein ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity