50539

• Gene Symbol: Smad2
• Gene Name: SMAD family member 2
• Gene Aliases: Madh2
• Chromosome Location: Chr.18: 72550105 - 72612078 on Build Rnor_6.0
• UniGene ID: Rn.2755
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Smad2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001277450.1	NP_001264379.1	2	325
	NM_019191.2	NP_062064.1	2	353
	XM_006254945.2	XP_006255007.1	2	439
GenBank mRNA	AB010147.1	-	1	127
	AB017912.1	-	2	219
	AF056001.1	-	2	253
	BC127497.1	-	2	197	8364718
	FQ230791.1	-	2	191

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001252481, NM_010754, AK007817, BC021342, BC089184, and others.

Panther Classification:

Molecular Function -

DNA-binding transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

ureteric bud development
in utero embryonic development
endoderm formation
mesoderm formation
transcription, DNA-templated
protein phosphorylation
transforming growth factor beta receptor signaling pathway
common-partner SMAD protein phosphorylation
SMAD protein complex assembly
zygotic specification of dorsal/ventral axis
gastrulation
pattern specification process
endoderm development
heart development
negative regulation of cell proliferation
response to glucose
post-embryonic development
embryonic pattern specification
anterior/posterior pattern specification
positive regulation of gene expression
negative regulation of gene expression
positive regulation of epithelial to mesenchymal transition
regulation of transforming growth factor beta receptor signaling pathway
signal transduction involved in regulation of gene expression
insulin secretion
lung development
positive regulation of BMP signaling pathway
pancreas development
activin receptor signaling pathway
organ growth
intracellular signal transduction
nodal signaling pathway
cell fate commitment
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
paraxial mesoderm morphogenesis
developmental growth
embryonic foregut morphogenesis
embryonic cranial skeleton morphogenesis
regulation of binding
palate development
pericardium development
SMAD protein signal transduction
response to cholesterol
positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
chromatin binding
double-stranded DNA binding
transcription factor activity, sequence-specific DNA binding
transforming growth factor beta receptor binding
protein binding
transcription factor binding
phosphatase binding
transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
ubiquitin protein ligase binding
activating transcription factor binding
type I transforming growth factor beta receptor binding
protein homodimerization activity
SMAD binding
metal ion binding
protein heterodimerization activity
co-SMAD binding
I-SMAD binding
R-SMAD binding