50991

• Gene Symbol: Park2
• Gene Name: parkin RBR E3 ubiquitin protein ligase
• Gene Aliases: Park, Prkn
• Chromosome Location: Chr.1: 48880015 - 50069998 on Build Rnor_6.0
• UniGene ID: Rn.207194
• Species: Rat
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Park2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_020093.1	NP_064478.1	2	159
GenBank mRNA	AB039878.1	-	2	159
	AF168004.1	-	2	179
	AF210434.1	-	2	151
	AF257234.1	-	1	89
	AF343574.1	-	1	89
	AF381277.1	-	1	89
	AF381278.1	-	1	89
	AF381279.1	-	1	89
	AF381280.1	-	1	89
	AF381281.1	-	1	89
	GU322017.1	-	2	102
	GU322019.1	-	2	102
	GU322363.1	-	2	102
	GU322364.1	-	2	102
	GU345835.1	-	2	102
	GU345836.1	-	2	102
	KC774176.1	-	1	109

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_016694, GU272056, AF250294, FJ555557, AF250293, and others.

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

protein polyubiquitination
mitochondrial fission
mitophagy
negative regulation of protein phosphorylation
synaptic transmission, dopaminergic
startle response
transcription, DNA-templated
cellular protein modification process
ubiquitin-dependent protein catabolic process
protein monoubiquitination
response to oxidative stress
response to unfolded protein
mitochondrion organization
learning
locomotory behavior
adult locomotory behavior
regulation of autophagy
positive regulation of mitochondrial fusion
negative regulation of mitochondrial fusion
regulation of mitochondrion organization
protein ubiquitination
protein metabolic process
regulation of protein ubiquitination
negative regulation of actin filament bundle assembly
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of glucokinase activity
response to endoplasmic reticulum stress
synaptic transmission, glutamatergic
norepinephrine metabolic process
dopamine metabolic process
response to drug
neuron maturation
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
positive regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of DNA binding
negative regulation of neuron apoptotic process
cellular protein catabolic process
negative regulation by host of viral genome replication
positive regulation of transcription from RNA polymerase II promoter
negative regulation of JNK cascade
negative regulation of insulin secretion
regulation of neurotransmitter secretion
modulation of synaptic transmission
protein stabilization
regulation of protein transport
response to corticosterone
dopamine uptake involved in synaptic transmission
mitochondrion localization
protein autoubiquitination
zinc ion homeostasis
negative regulation of cell death
neuron cellular homeostasis
protein K63-linked ubiquitination
protein localization to mitochondrion
aggresome assembly
protein K48-linked ubiquitination
positive regulation of mitochondrial fission
negative regulation of release of cytochrome c from mitochondria
cellular response to toxic substance
regulation of cellular response to oxidative stress
negative regulation of neuron death
positive regulation of proteasomal protein catabolic process
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
positive regulation of protein linear polyubiquitination
negative regulation of oxidative stress-induced neuron death
positive regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
regulation of reactive oxygen species metabolic process
negative regulation of reactive oxygen species metabolic process

Function(s)

transcription regulatory region sequence-specific DNA binding
G-protein coupled receptor binding
actin binding
ubiquitin-protein transferase activity
protein binding
zinc ion binding
tubulin binding
ligase activity
kinase binding
protein kinase binding
PDZ domain binding
Hsp70 protein binding
heat shock protein binding
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
protein complex binding
identical protein binding
histone deacetylase binding
ubiquitin binding
chaperone binding
ubiquitin protein ligase activity
cullin family protein binding
ubiquitin-specific protease binding
F-box domain binding