5348

• Gene Symbol: PPARA
• Gene Name: peroxisome proliferator activated receptor alpha
• Gene Aliases: NR1C1, PPAR, PPARalpha, hPPAR
• Chromosome Location: Chr.22: 46150534 - 46243756 on Build GRCh38
• UniGene ID: Hs.103110
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PPARA
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001001928.2	NP_001001928.1	3	319
	NM_005036.4	NP_005027.2	4	403
	XM_005261655.3	XP_005261712.1	4	696
	XM_005261656.3	XP_005261713.1	5	860
	XM_006724269.3	XP_006724332.1	4	462
	XM_006724270.3	XP_006724333.1	3	368
	XM_011530239.2	XP_011528541.1	5	552
	XM_011530240.2	XP_011528542.1	5	555
	XM_011530241.2	XP_011528543.1	4	460
	XM_011530242.2	XP_011528544.1	3	282
	XM_011530243.2	XP_011528545.1	2	523
	XM_011530244.2	XP_011528546.1	5	555
	XM_011530245.2	XP_011528547.1	3	371
	XM_017028839.1	XP_016884328.1	5	552
	XM_017028840.1	XP_016884329.1	5	555
GenBank mRNA	AB307690.1	-	1	137
	AK289821.1	-	4	696
	BC000052.2	-	3	347
	CR456547.1	-	2	273
	CR457435.1	-	1	137
	EU395809.1	-	1	137
	EU650667.1	-	1	137
	HQ692862.1	-	1	137
	L02932.1	-	3	353
	S74349.1	-	2	260
	Y07619.1	-	1	137

More Information

Panther Classification:

Molecular Function -

C4 zinc finger nuclear receptor, DNA-binding transcription factor, zinc finger transcription factor, gene-specific transcriptional regulator

Gene Ontology Categories:

Process(es)

negative regulation of transcription from RNA polymerase II promoter
response to hypoxia
transcription initiation from RNA polymerase II promoter
lipid metabolic process
fatty acid metabolic process
heart development
epidermis development
negative regulation of macrophage derived foam cell differentiation
negative regulation of receptor biosynthetic process
negative regulation of cholesterol storage
negative regulation of sequestering of triglyceride
fatty acid transport
intracellular receptor signaling pathway
positive regulation of fatty acid beta-oxidation
negative regulation of protein binding
negative regulation of appetite
response to insulin
circadian regulation of gene expression
behavioral response to nicotine
wound healing
lipoprotein metabolic process
regulation of circadian rhythm
steroid hormone mediated signaling pathway
cellular lipid metabolic process
positive regulation of gluconeogenesis
negative regulation of blood pressure
negative regulation of glycolytic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
positive regulation of fatty acid oxidation
negative regulation of inflammatory response
enamel mineralization
regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter
regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter
negative regulation of neuron death
negative regulation of pri-miRNA transcription from RNA polymerase II promoter
negative regulation of leukocyte cell-cell adhesion
negative regulation of transcription regulatory region DNA binding

Function(s)

RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
RNA polymerase II repressing transcription factor binding
transcriptional activator activity, RNA polymerase II transcription factor binding
transcription coactivator binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
transcription factor binding
drug binding
zinc ion binding
lipid binding
phosphatase binding
protein domain specific binding
ubiquitin conjugating enzyme binding
protein complex binding
sequence-specific DNA binding
NFAT protein binding
MDM2/MDM4 family protein binding