5643

• Gene Symbol: PTPN22
• Gene Name: protein tyrosine phosphatase, non-receptor type 22
• Gene Aliases: LYP, LYP1, LYP2, PEP, PTPN8
• Chromosome Location: Chr.1: 113813811 - 113871761 on Build GRCh38
• UniGene ID: Hs.535276
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: PTPN22
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001193431.2	NP_001180360.1	1	210
	NM_001308297.1	NP_001295226.1	1	210
	NM_012411.5	NP_036543.4	1	210
	NM_015967.6	NP_057051.3	1	210
	XM_011541221.1	XP_011539523.1	1	191
	XM_011541222.1	XP_011539524.1	1	191
	XM_011541223.2	XP_011539525.1	1	191
	XM_011541225.2	XP_011539527.1	1	212
	XM_017001004.1	XP_016856493.1	1	191
	XM_017001006.1	XP_016856495.1	1	191
GenBank mRNA	AF001846.1	-	1	115
	AF077031.1	-	1	146
	AF150732.1	-	1	144
	AK303124.1	-	1	159
	AK310570.1	-	1	163
	AK310698.1	-	1	163
	BC017785.1	-	1	163
	BC071670.1	-	1	149	5497108
	CD692658.1	-	1	230
	DB145424.1	-	1	204
	DN997966.1	-	1	120
	GU479452.1	-	1	124
	JN084012.1	-	1	87

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001106460, XM_006233072, XM_008761379.

Gene Ontology Categories:

Process(es)

protein dephosphorylation
autophagy
negative regulation of autophagy
positive regulation of gene expression
negative regulation of gene expression
T cell differentiation
lipopolysaccharide-mediated signaling pathway
positive regulation of type I interferon production
response to lipopolysaccharide
negative regulation of tumor necrosis factor production
regulation of natural killer cell proliferation
positive regulation of toll-like receptor 3 signaling pathway
positive regulation of toll-like receptor 4 signaling pathway
peptidyl-tyrosine dephosphorylation
phosphoanandamide dephosphorylation
negative regulation of JUN kinase activity
regulation of innate immune response
regulation of B cell receptor signaling pathway
negative regulation of T cell receptor signaling pathway
negative regulation of T cell activation
positive regulation of ERK1 and ERK2 cascade
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
cellular response to muramyl dipeptide
negative regulation of interleukin-6 secretion
regulation of NIK/NF-kappaB signaling
positive regulation of protein K63-linked ubiquitination
positive regulation of interferon-gamma secretion
negative regulation of p38MAPK cascade
negative regulation of interleukin-8 secretion

Function(s)

protein tyrosine phosphatase activity
protein binding
phosphatase activity
SH3 domain binding
kinase binding
ubiquitin protein ligase binding