69795

• Gene Symbol: Thbs1
• Gene Name: thrombospondin 1
• Gene Aliases: TSP-1, TSP1, Thbs-1, tbsp1
• Chromosome Location: Chr.2: 118111890 - 118127133 on Build GRCm38
• UniGene ID: Mm.4159
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Thbs1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011580.3	NP_035710.2	8, 9	1471
GenBank mRNA	AK080686.1	-	8, 9	1506
	AK145202.1	-	8, 9	1501
	AK163092.1	-	8, 9	1498
	BC020435.1	-	8, 9	1479
	BC042422.1	-	8, 9	1473	4018176
	BC050917.1	-	8, 9	1471	6405710
	M87276.1	-	8, 9	1497

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Human: AK291639, X14787.

Gene Ontology Categories:

Process(es)

activation of MAPK activity
negative regulation of endothelial cell proliferation
negative regulation of cell-matrix adhesion
sprouting angiogenesis
negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
negative regulation of dendritic cell antigen processing and presentation
outflow tract morphogenesis
endocardial cushion development
growth plate cartilage development
inflammatory response
response to unfolded protein
cell cycle arrest
cell adhesion
response to mechanical stimulus
response to glucose
positive regulation of endothelial cell migration
negative regulation of endothelial cell migration
negative regulation of plasma membrane long-chain fatty acid transport
negative regulation of nitric oxide mediated signal transduction
negative regulation of cGMP-mediated signaling
negative regulation of plasminogen activation
positive regulation of macrophage chemotaxis
positive regulation of fibroblast migration
positive regulation of cell-substrate adhesion
cell migration
negative regulation of angiogenesis
peptide cross-linking
positive regulation of blood coagulation
positive regulation of cell migration
positive regulation of transforming growth factor beta receptor signaling pathway
regulation of cGMP metabolic process
response to magnesium ion
negative regulation of interleukin-12 production
response to endoplasmic reticulum stress
negative regulation of fibroblast growth factor receptor signaling pathway
positive regulation of phosphorylation
positive regulation of tumor necrosis factor biosynthetic process
positive regulation of macrophage activation
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
engulfment of apoptotic cell
positive regulation of translation
positive regulation of angiogenesis
behavioral response to pain
blood vessel morphogenesis
positive regulation of chemotaxis
response to calcium ion
positive regulation of protein kinase B signaling
negative regulation of fibrinolysis
positive regulation of transforming growth factor beta production
cellular response to nitric oxide
positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
negative regulation of endothelial cell chemotaxis

Function(s)

phosphatidylserine binding
fibronectin binding
integrin binding
calcium ion binding
protein binding
heparin binding
fibroblast growth factor binding
low-density lipoprotein particle binding
laminin binding
transforming growth factor beta binding
extracellular matrix binding
fibrinogen binding
collagen V binding