HSS175502

Gene Symbol:

KLC3 ERCC2

Gene Name:

kinesin light chain 3

ERCC excision repair 2, TFIIH core complex helicase subunit

Gene Aliases:

KLC2, KLC2L, KLCt, KNS2B

COFS2, EM9, TFIIH, TTD, TTD1, XPD

Chromosome Location:

Chr.19: 45340740 - 45351520 on Build GRCh38

Chromosome Location:

Chr.19: 45349837 - 45370647 on Build GRCh38

UniGene ID:

Hs.298079

Hs.487294

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: KLC3
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_177417.2	NP_803136.2	12	1526
GenBank mRNA	AK092481.1	-	11	1553
	BC062998.1	-	12	1513	5172274
	BC073841.1	-	12	1502	5190809
	BC126418.1	-	11	1542	8992134
	BC133037.1	-	11	1542	40147059

Gene Symbol: ERCC2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	XM_011526611.2	XP_011524913.1	22	2952
	XM_017026467.1	XP_016881956.1	22	2866

More Information

Panther Classification:

Molecular Function -

cytoskeletal protein, microtubule binding motor protein, microtubule or microtubule-binding cytoskeletal protein, DNA helicase

Gene Ontology Categories:

Process(es)

axo-dendritic transport
nucleotide-excision repair, DNA duplex unwinding
response to hypoxia
in utero embryonic development
transcription-coupled nucleotide-excision repair
nucleotide-excision repair
nucleotide-excision repair, preincision complex stabilization
nucleotide-excision repair, preincision complex assembly
nucleotide-excision repair, DNA incision, 3'-to lesion
nucleotide-excision repair, DNA incision, 5'-to lesion
transcription initiation from RNA polymerase I promoter
transcription elongation from RNA polymerase I promoter
termination of RNA polymerase I transcription
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
transcription elongation from RNA polymerase II promoter
7-methylguanosine mRNA capping
protein phosphorylation
apoptotic process
response to oxidative stress
chromosome segregation
aging
cell proliferation
UV protection
post-embryonic development
viral process
spinal cord development
extracellular matrix organization
bone mineralization
central nervous system myelin formation
nucleotide-excision repair, DNA incision
multicellular organism growth
hair cell differentiation
embryonic cleavage
erythrocyte maturation
positive regulation of DNA binding
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
hair follicle maturation
hematopoietic stem cell differentiation
global genome nucleotide-excision repair
regulation of mitotic cell cycle phase transition

Function(s)

microtubule motor activity
protein binding
microtubule binding
kinesin binding
DNA binding
ATP-dependent DNA helicase activity
protein kinase activity
ATP binding
protein C-terminus binding
DNA-dependent ATPase activity
RNA polymerase II carboxy-terminal domain kinase activity
5'-3' DNA helicase activity
metal ion binding
protein N-terminus binding
4 iron, 4 sulfur cluster binding