HSS189993

• Gene Symbol: ARHGEF2
• Gene Name: Rho/Rac guanine nucleotide exchange factor 2
• Gene Aliases: GEF, GEF-H1, GEFH1, LFP40, P40
• Chromosome Location: Chr.1: 155946839 - 155991263 on Build GRCh38
• UniGene ID: Hs.743352
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: ARHGEF2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001162383.1	NP_001155855.1	17	2243
	NM_001162384.1	NP_001155856.1	17	2240
	NM_004723.3	NP_004714.2	17	2168
	XM_005245587.2	XP_005245644.1	17	2296
	XM_005245588.2	XP_005245645.1	17	2293
	XM_005245589.4	XP_005245646.1	17	2449
	XM_005245590.3	XP_005245647.1	17	2171
	XM_005245591.3	XP_005245648.1	18	2287
	XM_005245592.2	XP_005245649.1	17	2440
	XM_005245593.4	XP_005245650.1	17	2171
	XM_005245594.2	XP_005245651.1	17	3157
	XM_006711622.3	XP_006711685.1	17	3434
	XM_006711623.3	XP_006711686.1	16	2170
	XM_006711624.3	XP_006711687.1	16	2197
	XM_006711625.3	XP_006711688.1	16	2103
	XM_006711626.2	XP_006711689.1	16	3089
	XM_011510136.2	XP_011508438.2	21	2852
	XM_011510137.2	XP_011508439.2	21	2855
	XM_011510139.2	XP_011508441.1	21	2855
	XM_011510141.2	XP_011508443.1	17	2973
	XM_011510143.2	XP_011508445.1	13	1719
	XM_017002794.1	XP_016858283.1	21	2852
	XM_017002795.1	XP_016858284.1	17	2187
	XM_017002796.1	XP_016858285.1	17	3431
	XM_017002797.1	XP_016858286.1	17	2171
	XM_017002798.1	XP_016858287.1	16	3366
	XM_017002799.1	XP_016858288.1	16	2167
GenBank mRNA	AB014551.3	-	21	2511
	AF486838.1	-	17	2122
	AL512715.1	-	17	2153
	BC020567.1	-	17	2225	4157775
	BT007407.1	-	16	2044
	U72206.1	-	17	2227
	X15610.1	-	3	235

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Mouse: NM_001198912, NM_001198911, NM_008487, NM_001198913, AF177032, and others.

Gene Ontology Categories:

Process(es)

establishment of mitotic spindle orientation
cell morphogenesis
intracellular protein transport
actin filament organization
negative regulation of microtubule depolymerization
mitotic nuclear division
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of Rho protein signal transduction
intracellular signal transduction
regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of GTPase activity
innate immune response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
regulation of small GTPase mediated signal transduction
positive regulation of NF-kappaB transcription factor activity
cell division
negative regulation of necroptotic process
cellular response to muramyl dipeptide
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress

Function(s)

guanyl-nucleotide exchange factor activity
Rho guanyl-nucleotide exchange factor activity
protein binding
microtubule binding
transcription factor binding
zinc ion binding
Rho GTPase binding
Rac guanyl-nucleotide exchange factor activity
Rac GTPase binding