s22120

• Gene Symbol: CHEK2
• Gene Name: checkpoint kinase 2
• Gene Aliases: CDS1, CHK2, HuCds1, LFS2, PP1425, RAD53, hCds1
• Chromosome Location: Chr.22: 28687743 - 28741866 on Build GRCh38
• UniGene ID: Hs.291363
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: CHEK2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001005735.1	NP_001005735.1	14	1625
	NM_001257387.1	NP_001244316.1	14	1610
	NM_007194.3	NP_009125.1	13	1496
	NM_145862.2	NP_665861.1	12	1409
	XM_006724114.3	XP_006724177.2	9	1139
	XM_006724116.2	XP_006724179.2	9	884
	XM_011529839.2	XP_011528141.1	14	1647
	XM_011529840.2	XP_011528142.1	13	1562
	XM_011529841.1	XP_011528143.1	13	1428
	XM_011529842.2	XP_011528144.1	12	1316
	XM_011529843.1	XP_011528145.1	12	1295
	XM_011529845.2	XP_011528147.1	12	1203
	XM_017028560.1	XP_016884049.1	14	1611
	XM_017028561.1	XP_016884050.1	10	855
GenBank mRNA	AB040105.1	-	11	1337
	AF086904.1	-	12	1424
	AF096279.1	-	12	1424
	AF174135.1	-	12	1424
	AF217975.1	-	14	2209
	AJ131197.1	-	12	1424
	AK289360.1	-	13	1475
	AK290754.1	-	13	1498
	AY551295.1	-	4	470
	AY551296.1	-	5	582
	AY551297.1	-	13	1553
	AY551298.1	-	11	1362
	AY551299.1	-	11	1337
	AY551301.1	-	12	1314
	AY551302.1	-	11	1333
	AY551303.1	-	10	1151
	AY551305.1	-	13	1538
	BC004207.2	-	13	1451	3532866
	CR456418.1	-	14	1624

More Information

Panther Classification:

Molecular Function -

non-receptor serine/threonine protein kinase

Gene Ontology Categories:

Process(es)

DNA damage checkpoint
G2/M transition of mitotic cell cycle
replicative cell aging
positive regulation of protein phosphorylation
double-strand break repair
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
cellular response to DNA damage stimulus
DNA damage induced protein phosphorylation
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
intrinsic apoptotic signaling pathway in response to DNA damage
response to gamma radiation
peptidyl-serine phosphorylation
cellular response to drug
regulation of protein catabolic process
signal transduction in response to DNA damage
cellular protein catabolic process
positive regulation of transcription, DNA-templated
protein autophosphorylation
protein stabilization
cell division
negative regulation of cell cycle arrest
signal transduction involved in intra-S DNA damage checkpoint
mitotic spindle assembly
replicative senescence
regulation of signal transduction by p53 class mediator
response to doxorubicin
cellular response to bisphenol A
negative regulation of DNA damage checkpoint
positive regulation of anoikis

Function(s)

protein serine/threonine kinase activity
protein binding
ATP binding
protein kinase binding
ubiquitin protein ligase binding
identical protein binding
protein homodimerization activity
metal ion binding