s274 Validated

Gene Symbol:

EGLN2 RAB4B-EGLN2

Gene Name:

egl-9 family hypoxia inducible factor 2

RAB4B-EGLN2 readthrough (NMD candidate)

Gene Aliases:

EIT6, HIF-PH1, HIFPH1, HPH-1, HPH-3, PHD1

RERT-lncRNA

Chromosome Location:

Chr.19: 40799143 - 40808441 on Build GRCh38

Chromosome Location:

Chr.19: 40778219 - 40808441 on Build GRCh38

UniGene ID:

Hs.515417

Hs.631539

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: EGLN2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_053046.3	NP_444274.1	3	1370
	NM_080732.3	NP_542770.2	3	1280
GenBank mRNA	AJ310544.1	-	2	1222
	AK026863.1	-	1	316
	AK074408.1	-	3	1209
	AK098182.1	-	2	1954
	AK314741.1	-	1	638
	AL133009.1	-	1	2565
	AL832506.1	-	3	1236
	AY040565.1	-	2	1214
	BC001723.1	-	3	1183
	BC036051.1	-	3	1284	5270945

Gene Symbol: RAB4B-EGLN2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NR_037791.1		9	1974
GenBank mRNA	AK291385.1	-	9	1922

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001004083, XM_006228575, XM_006228574, BC081858, AY229997, and others.
This siRNA also targets the following transcripts in Mouse: NM_053208, BC086764, AK152056, AK166661, AJ310547, and others.

Matching Taqman Gene Expression Assay:

Hs00363196_m1

Gene Ontology Categories:

Process(es)

regulation of cell growth
response to hypoxia
peptidyl-proline hydroxylation to 4-hydroxy-L-proline
intracellular estrogen receptor signaling pathway
regulation of neuron apoptotic process
cell redox homeostasis
positive regulation of protein catabolic process
oxidation-reduction process
regulation of transcription from RNA polymerase II promoter in response to hypoxia

Function(s)

protein binding
ferrous iron binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
oxygen sensor activity
L-ascorbic acid binding
peptidyl-proline 4-dioxygenase activity