s32797 Validated

• Gene Symbol: SMURF1
• Gene Name: SMAD specific E3 ubiquitin protein ligase 1
• Gene Aliases: -
• Chromosome Location: Chr.7: 99027435 - 99144120 on Build GRCh38
• UniGene ID: Hs.189329
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: SMURF1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001199847.1	NP_001186776.1	14	1971
	NM_020429.2	NP_065162.1	15	2049
	NM_181349.2	NP_851994.1	14	1971
	XM_017012457.1	XP_016867946.1	15	2047
GenBank mRNA	AB046845.1	-	15	2017
	AF199364.2	-	14	1604
	AF464850.1	-	15	1709
	AL834242.1	-	3	332
	BC136804.1	-	14	1848	9020794
	BC144414.1	-	14	1848	9052935
	BC152468.1	-	15	2017	8862605

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001109598, XM_006248882, XM_008769002.
This siRNA also targets the following transcripts in Mouse: NM_001038627, NM_029438, AK034736, AK154491, BC029097, and others.

Matching Taqman Gene Expression Assay:

Hs00410929_m1

Panther Classification:

Molecular Function -

ubiquitin-protein ligase

Gene Ontology Categories:

Process(es)

protein polyubiquitination
positive regulation of defense response to virus by host
protein export from nucleus
transforming growth factor beta receptor signaling pathway
ectoderm development
protein ubiquitination
cell differentiation
negative regulation of ossification
BMP signaling pathway
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of BMP signaling pathway
ubiquitin-dependent SMAD protein catabolic process
receptor catabolic process
protein localization to cell surface
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
Wnt signaling pathway, planar cell polarity pathway
engulfment of target by autophagosome
protein targeting to vacuole involved in autophagy
protein targeting to plasma membrane
mitophagy in response to mitochondrial depolarization
positive regulation of dendrite extension
positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Function(s)

ubiquitin-protein transferase activity
protein binding
phospholipid binding
ligase activity
activin binding
ubiquitin protein ligase activity
I-SMAD binding
R-SMAD binding