s39012

• Gene Symbol: DOT1L
• Gene Name: DOT1 like histone lysine methyltransferase
• Gene Aliases: DOT1, KMT4
• Chromosome Location: Chr.19: 2163963 - 2232578 on Build GRCh38
• UniGene ID: Hs.713641
• Species: Human
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: DOT1L
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_032482.2	NP_115871.1	11, 12	1003
	XM_005259659.3	XP_005259716.1	11, 12	1189
	XM_005259660.3	XP_005259717.1	11, 12	1189
	XM_011528359.2	XP_011526661.1	11, 12	1189
	XM_011528360.1	XP_011526662.1	12, 13	1047
	XM_011528361.2	XP_011526663.1	3, 4	408
	XM_017027366.1	XP_016882855.1	11, 12	1152
GenBank mRNA	AF509504.1	-	11, 12	1003
	AK074120.1	-	7, 8	668

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_001108733, XM_006240961, XM_006240960, XM_006240959.
This siRNA also targets the following transcripts in Mouse: NM_199322, AY377920, AY196089, JF508521, AK035144, and others.

Panther Classification:

Molecular Function -

chromatin/chromatin-binding, or -regulatory protein, histone modifying enzyme

Gene Ontology Categories:

Process(es)

chromatin silencing
positive regulation of cell proliferation
telomere organization
histone H3-K79 methylation
positive regulation of transcription from RNA polymerase II promoter
regulation of JAK-STAT cascade
regulation of cell cycle
regulation of transcription regulatory region DNA binding

Function(s)

DNA binding
protein binding
histone-lysine N-methyltransferase activity
histone methyltransferase activity (H3-K79 specific)
histone methyltransferase activity