s55346

Gene Symbol:

DHFR2 DHFR

Gene Name:

dihydrofolate reductase 2

dihydrofolate reductase

Gene Aliases:

DHFRL1, DHFRP4

DHFRP1, DYR

Chromosome Location:

Chr.3: 94057922 - 94063656 on Build GRCh38

Chromosome Location:

Chr.5: 80626226 - 80654981 on Build GRCh38

UniGene ID:

Hs.718516

Hs.592364

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: DHFR2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001195643.1	NP_001182572.1	2	811
	NM_176815.4	NP_789785.1	2	698
	XM_011512537.2	XP_011510839.1	2	876
GenBank mRNA	AK122674.1	-	2	811
	AL832912.1	-	2	487
	BC045541.1	-	2	529	5262102
	BC063379.1	-	2	487	4109721

Gene Symbol: DHFR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000791.3	NP_000782.1	4, 5	853
	NM_001290354.1	NP_001277283.1	3, 4	803
GenBank mRNA	AK293146.1	-	3, 4	381
	AK312642.1	-	1	397
	BC000192.1	-	4, 5	416	3352539
	BC003584.1	-	5, 6	815	3354190
	BC070280.1	-	4, 5	398	6714220
	BC071996.1	-	5, 6	815	4645596
	EU145592.1	-	1	361
	J00140.1	-	4, 5	403
	V00507.1	-	1	361

More Information

Panther Classification:

Molecular Function -

reductase

Gene Ontology Categories:

Process(es)

glycine biosynthetic process
one-carbon metabolic process
nucleotide biosynthetic process
thymidine biosynthetic process
tetrahydrofolate metabolic process
tetrahydrofolate biosynthetic process
oxidation-reduction process
G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
tetrahydrobiopterin biosynthetic process
axon regeneration
response to methotrexate
dihydrofolate metabolic process
folic acid metabolic process
positive regulation of nitric-oxide synthase activity
regulation of removal of superoxide radicals

Function(s)

mRNA binding
dihydrofolate reductase activity
NADP binding
folic acid binding
drug binding
folate reductase activity
methotrexate binding
NADPH binding