s55346

Gene Symbol:

DHFR DHFR2

Gene Name:

dihydrofolate reductase

dihydrofolate reductase 2

Gene Aliases:

DHFRP1, DYR

DHFRL1, DHFRP4

Chromosome Location:

Chr.5: 80626226 - 80654981 on Build GRCh38

Chromosome Location:

Chr.3: 94057922 - 94063656 on Build GRCh38

UniGene ID:

Hs.592364

Hs.718516

Species:

Human

Species Specific ID (Flybase ID):

-

-

siRNA Details

Gene Symbol: DHFR
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_000791.3	NP_000782.1	4, 5	853
	NM_001290354.1	NP_001277283.1	3, 4	803
GenBank mRNA	AK293146.1	-	3, 4	381
	AK312642.1	-	1	397
	BC000192.1	-	4, 5	416	3352539
	BC003584.1	-	5, 6	815	3354190
	BC070280.1	-	4, 5	398	6714220
	BC071996.1	-	5, 6	815	4645596
	EU145592.1	-	1	361
	J00140.1	-	4, 5	403
	V00507.1	-	1	361

Gene Symbol: DHFR2
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_001195643.1	NP_001182572.1	2	811
	NM_176815.4	NP_789785.1	2	698
	XM_011512537.2	XP_011510839.1	2	876
GenBank mRNA	AK122674.1	-	2	811
	AL832912.1	-	2	487
	BC045541.1	-	2	529	5262102
	BC063379.1	-	2	487	4109721

More Information

Panther Classification:

Molecular Function -

reductase

Gene Ontology Categories:

Process(es)

G1/S transition of mitotic cell cycle
regulation of transcription involved in G1/S transition of mitotic cell cycle
glycine biosynthetic process
tetrahydrobiopterin biosynthetic process
one-carbon metabolic process
nucleotide biosynthetic process
axon regeneration
response to methotrexate
dihydrofolate metabolic process
tetrahydrofolate metabolic process
tetrahydrofolate biosynthetic process
folic acid metabolic process
positive regulation of nitric-oxide synthase activity
oxidation-reduction process
regulation of removal of superoxide radicals
thymidine biosynthetic process

Function(s)

mRNA binding
dihydrofolate reductase activity
folic acid binding
drug binding
folate reductase activity
methotrexate binding
NADPH binding
NADP binding