s72431

• Gene Symbol: Ptpn1
• Gene Name: protein tyrosine phosphatase, non-receptor type 1
• Gene Aliases: PTP-1B, PTP-HA2, PTP1B
• Chromosome Location: Chr.2: 167932303 - 167979385 on Build GRCm38
• UniGene ID: Mm.277916
• Species: Mouse
• Species Specific ID (Flybase ID): -

siRNA Details

Gene Symbol: Ptpn1
Interrogated Sequence		Translated Protein	Targeted Exon(s)	siRNA Location	IMAGE Clone ID
RefSeq	NM_011201.3	NP_035331.3	6, 7	867
GenBank mRNA	AK149979.1	-	6, 7	823
	AK150322.1	-	6, 7	823
	AK151371.1	-	6, 7	780
	AK153088.1	-	6, 7	805
	AK156281.1	-	6, 7	829
	AK157431.1	-	6, 7	868
	AK165567.1	-	6, 7	832
	AK165949.1	-	7, 8	947
	AK166020.1	-	6, 7	823
	AK168255.1	-	6, 7	805
	AK168772.1	-	6, 7	822
	AK170620.1	-	6, 7	823
	AK171380.1	-	6, 7	823
	AK172206.1	-	7, 8	940
	AK185819.1	-	1, 2	50
	AK208930.1	-	1, 2	50
	BC005729.1	-	1, 2	220
	BC010191.1	-	6, 7	785	3156854
	M97590.1	-	6, 7	783

More Information

Other Species Targeted

This siRNA also targets the following transcripts in Rat: NM_012637, XM_006235638, XM_006235639, BC081829, M33962.

Panther Classification:

Molecular Function -

protein phosphatase

Gene Ontology Categories:

Process(es)

protein dephosphorylation
activation of JUN kinase activity
insulin receptor signaling pathway
regulation of signal transduction
dephosphorylation
regulation of endocytosis
negative regulation of vascular endothelial growth factor receptor signaling pathway
endoplasmic reticulum unfolded protein response
actin cytoskeleton reorganization
regulation of intracellular protein transport
response to endoplasmic reticulum stress
peptidyl-tyrosine dephosphorylation
platelet-derived growth factor receptor-beta signaling pathway
IRE1-mediated unfolded protein response
negative regulation of MAP kinase activity
regulation of insulin receptor signaling pathway
positive regulation of protein tyrosine kinase activity
negative regulation of ERK1 and ERK2 cascade
regulation of hepatocyte growth factor receptor signaling pathway
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
negative regulation of PERK-mediated unfolded protein response
peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
positive regulation of receptor catabolic process

Function(s)

phosphoprotein phosphatase activity
protein tyrosine phosphatase activity
insulin receptor binding
zinc ion binding
hydrolase activity
phosphatase activity
enzyme binding
protein kinase binding
receptor tyrosine kinase binding
poly(A) RNA binding
ephrin receptor binding
protein phosphatase 2A binding