α-1-Antitrypsin Ab-1 Rabbit Polyclonal Antibody, Epredia™

Obtain accurate, reproducible results with Epredia™ α-1-Antitrypsin Ab-1, Rabbit Polyclonal Antibody.

Catalog Number	Mfr. No.	Quantity	Form
RB367A	Epredia RB367A	1 mL	Concentrated
RB367A1	Epredia RB367A1	500 μL	Concentrated
RB367R7	Epredia RB367R7	7 mL	Ready to Use
RB367R1	Epredia RB367R1	1 mL

Description

Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Baboon, Monkey, Horse and Mink. Does not react with cow, kangaroo, pig, goat, sheep, cat, dog, guinea pig, mouse and chicken. Others not known.

Immunogen: Purified human serum α-1-AT

Positive Control: Tonsil

Cellular Localization: Cytoplasmic

Recommended for:

• Immunohistochemistry (Formalin/paraffin)

Note:

USA: RUO; Int'l: RUO

Specifications

• Antigen: alpha-1-Antitrypsin Ab-1
• Classification: Polyclonal
• Host Species: Rabbit
• Research Discipline: Enzyme
• Isotype: IgG

• Applications: Immunohistochemistry (Paraffin)
• Conjugate: Unconjugated
• Regulatory Status: RUO
• Immunogen: Purified human serum alpha-1-AT