2,2,2-Trifluoroethanol, 99+%, Thermo Scientific Chemicals

Description

Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Trifluoroethanol serves as a solvent and a raw material in organic chemistry and biology. TFE is a solvent of choice for hydrogen peroxide-mediated oxidations of sulfides. Trifluoroethanol acts as a protein denaturant. It is used in the manufacture of certain pharmaceuticals and drug substances. The drug fluromer, which is 2,2,2-trifluoro-1-vinyloxyethane, is the vinyl ether of trifluorethanol. It is an effective solvent for peptides and proteins, and used for NMR-based protein folding studies, and in the manufacture of nylon. As a source of the trifluoromethyl group, it is employed in several organic reactions, for example in Still-Gennari modification of Horner-Wadsworth-Emmons reaction (HWE) reaction.

Solubility
Miscible with water, ethers, ketones, alcohols and chloroform.

Notes
Moisture sensitive.

Specifications

• Melting Point: -44°C
• Density: 1.391
• Boiling Point: 74°C to 75°C
• Flash Point: 29°C (84°F)
• Refractive Index: 1.29
• Linear Formula: CF₃CH₂OH
• Quantity: 50 g
• UN Number: UN1992
• Beilstein: 1733203
• Solubility Information: Miscible with water,ethers,ketones,alcohols and chloroform.
• IUPAC Name: 2,2,2-trifluoroethan-1-ol
• Formula Weight: 100.04
• Percent Purity: ≥99%
• Chemical Name or Material: 2,2,2-Trifluoroethanol

Safety and Handling

Hazard Category	H226-H301+H331-H318-H360F-H373
Hazard Statement	GHS H Statement H301-H311-H318-H226-H332-H315-H335 Toxic if swallowed. Toxic in contact with skin. Causes serious eye damage. Flammable liquid and vapor. Harmful if inhaled. Causes skin irritation. May cause respiratory irritation.
Precautionary Statement	P201-P202-P210-P233-P235-P240-P241-P242-P243-P260-P264b-P270-P271-P281-P301+P310-P303+P361+P353-P304+P340-P305+P351+P338-P308+P313-P310-P311-P330-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: FLAMMABLE LIQUIDS, TOXIC, N.O.S.
EINECSNumber	200-913-6
RTECSNumber	KM5250000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only