Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Tocris™ 3-MATIDA

Potent, selective mGlu1 antagonist

Manufacturer:  Tocris™ 2196/50

 View more versions of this product

Catalog No. 21-965-0

  Check Availability
Add to cart


For Research Use Only



Potent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3µM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300µM), NMDA and AMPA (IC50 = 250µM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.
  • Chemical Name: α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid
  • Formula: C8H9NO4S
  • CAS Number: 518357-51-2
  • Solubility: Soluble to 100mM in 1eq. NaOH and to 50mM in DMSO
  • Purity: >99
Description & Specifications


Provide Content Correction

We continue to work to improve your shopping experience and your feedback regarding this content is very important to us. Please use the form below to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Cancel Submit