Potent, selective mGlu1 antagonist
Manufacturer: Tocris 2196/50
DescriptionPotent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3µM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300µM), NMDA and AMPA (IC50 = 250µM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.
- Chemical Name: α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid
- Formula: C8H9NO4S
- CAS Number: 518357-51-2
- Solubility: Soluble to 100mM in 1eq. NaOH and to 50mM in DMSO
- Purity: >99
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