Tocris™ 3-MATIDA

Potent, selective mGlu1 antagonist

Manufacturer: Tocris™ 2196/50

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Catalog No. 21-965-0

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For Research Use Only


    Product Type 3-MATIDA
    Inhibitors 3-MATIDA
    Purity >99
    Molecular Weight 215.23
    Quantity 50mg

    Potent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3µM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300µM), NMDA and AMPA (IC50 = 250µM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo.

    • Chemical Name: α-Amino-5-carboxy-3-methyl-2-thiopheneacetic acid
    • Formula: C8H9NO4S
    • CAS Number: 518357-51-2
    • Solubility: Soluble to 100mM in 1eq. NaOH and to 50mM in DMSO
    • Purity: >99

  • Description & Specifications

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