3-Methylcytosine Rabbit anti-Human, Mouse, Polyclonal, Invitrogen
Rabbit Polyclonal Antibody
Manufacturer: Invitrogen PA540098
Description3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.
|-20°C or -80°C if preferred|
|PBS with 0.05% Proclin 300, 0.05% sodium azide; pH 7.4|
|3mc; 3-mC; 3-meC; C5H7NO3; 3-Methyl-cytosine|
|Human BSA-conjugated 3-methylcytosine (3-mC).|
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