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3-Methylcytosine (3-mC) Polyclonal Antibody, Active Motif™
Rabbit Polyclonal Antibody
Supplier: Active Motif 61180
Description
3-methylcytosine arises by erroneous methylation of DNA through spontaneous exposure to endogenous S-adenosyl methionine (SAM). Since the N3-position in cytosine is protected in double stranded DNA, this phenomenon mainly occurs in single stranded DNA. The resulting 3-mC is toxic and mutagenic and increased levels of 3-mC seem to impair cell proliferation. Therefore, it has to be repaired by the cell. This is established by oxidative demethylation, which is catalyzed by the AlkB protein.Specifications
| 3-Methylcytosine (3-mC) | |
| Polyclonal | |
| Unconjugated | |
| 3mc; 3-mC; 3-meC; 3-Methyl-cytosine; C5H7NO3 | |
| This 3-methylcytosine antibody was raised against 3-methylcytidine conjugated to kLH and recognizes 3-methylcytosine . | |
| RUO | |
| Human, Mouse | |
| Antibody | |
| IgG |
| Dot Blot | |
| Conc. Not Determined | |
| whole serum with 30% glycerol and 0.035% sodium azide; pH | |
| Rabbit | |
| 10 μL | |
| Primary | |
| -20°C, Avoid Freeze/Thaw Cycles | |
| Liquid |
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