DescriptionPFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase) inhibitor; reduces glycolytic flux and suppresses glucose uptake. Inhibits endothelial cell proliferation and causes G2/M cell cycle arrest in vitro. Attenuates vessel sprouting and tumor growth in vivo. Amplifies the antiangiogenic effect of VEGFR blockade.
- Chemical Name: 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
- Formula: C13H10N2O
- CAS Number: 13309-08-5
- Solubility: Soluble to 100mM in DMSO
- Purity: >99
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