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Alfa Aesar™ 4-Chloro-2-(methylthio)pyrimidine, 98%

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Quantity:
10g
50g
250g
49844-90-8
C5H5ClN2S
160.619
MFCD00006083
DFOHHQRGDOQMKG-UHFFFAOYSA-N
4-chloro-2-methylthio pyrimidine,4-chloro-2-methylthiopyrimidine,4-chloro-2-methylsulfanyl pyrimidine,4-chloro-2-methylsulfanyl-pyrimidine,pyrimidine, 4-chloro-2-methylthio,4-chloro-2-methylmercapto pyrimidine,zlchem 575,pubchem15403,pubchem15764,acmc-1asbn
97113
4-chloro-2-methylsulfanylpyrimidine
CSC1=NC=CC(=N1)Cl
49844-90-8
C5H5ClN2S
160.619
MFCD00006083
DFOHHQRGDOQMKG-UHFFFAOYSA-N
4-chloro-2-methylthio pyrimidine,4-chloro-2-methylthiopyrimidine,4-chloro-2-methylsulfanyl pyrimidine,4-chloro-2-methylsulfanyl-pyrimidine,pyrimidine, 4-chloro-2-methylthio,4-chloro-2-methylmercapto pyrimidine,zlchem 575,pubchem15403,pubchem15764,acmc-1asbn
97113
4-chloro-2-methylsulfanylpyrimidine
CSC1=NC=CC(=N1)Cl
Applications
It finds it application as a building block used in medicinal chemistry synthesis. 4-Chloro-2-methylthiopyrimidine is used in the total synthesis of the marine alkaloid variolin B1 and 2-hydroxy-4-pyrimidinecarboxylic acid. It is also used in the synthesis of 2,4-disubstituted pyrimidines, a novel class of KDR kinase inhibitors.

Solubility
Not miscible or difficult to mix in water.

Notes
Moisture sensitive. Store away from oxidizing agents, bases, water/moisture, heat and light. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated.
Density 1.38
Refractive Index 1.6 00
Sensitivity Moisture sensitive; May form a precipitate
Melting Point ~-2°C
Quantity 10g
Boiling Point 118°C to 120°C (9mmHg)
Flash Point >110°C (230°F)
UN Number UN1760
Beilstein 118042
Solubility Information Not miscible or difficult to mix in water.
Formula Weight 160.63
Percent Purity 98%
Chemical Name or Material 4-Chloro-2-(methylthio)pyrimidine
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GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.

P260-P264b-P271-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

H314-H335

DOTInformation : Hazard Class: 8; Packaging Group: II

EINECSNumber : 256-500-6

TSCA : No

Recommended Storage : Store at -20°C