Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More

Alfa Aesar™ 4-Nitrobenzenesulfonyl chloride, 97%

Click to view available options
Quantity:
25g
100g
500g
98-74-8
C6H4ClNO4S
221.611
MFCD00007445
JXRGUPLJCCDGKG-UHFFFAOYSA-N
4-nitrobenzenesulfonylchloride,4-nitrobenzene-1-sulfonyl chloride,benzenesulfonyl chloride, 4-nitro,4-nitrobenzenesulphonyl chloride,4-nitrophenylsulfonyl chloride,p-nitrophenylsulfonyl chloride,4-nitrobenzenesulfonic acid chloride,p-nitrobenzenesulfonyl chloride,4-nitrobenzenesulphonylchloride,4-nitro-benzenesulfonyl chloride
7404
4-nitrobenzenesulfonyl chloride
C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)Cl
98-74-8
C6H4ClNO4S
221.611
MFCD00007445
JXRGUPLJCCDGKG-UHFFFAOYSA-N
4-nitrobenzenesulfonylchloride,4-nitrobenzene-1-sulfonyl chloride,benzenesulfonyl chloride, 4-nitro,4-nitrobenzenesulphonyl chloride,4-nitrophenylsulfonyl chloride,p-nitrophenylsulfonyl chloride,4-nitrobenzenesulfonic acid chloride,p-nitrobenzenesulfonyl chloride,4-nitrobenzenesulphonylchloride,4-nitro-benzenesulfonyl chloride
7404
4-nitrobenzenesulfonyl chloride
C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)Cl
Applications
4-Nitrobenzenesulfonyl chloride is used as an intermediate for the synthesis of pharmaceuticals like foscmprenavir, darunavir and amprenavir. It is involved in the preparation of N-nosyl-alpha-amino acid for peptide synthesis. It is also used for stereoselective α-glucosylation of partially protected carbohydrates in association with silver tri-fluoromethanesulfonate, N,N-dimethylacetamide and triethylamine. It is widely used for the synthesis of hydroxylamines of sulfadiazine, sulfamethoxazole and [Cu(bipy)2Cl](nbs) (1) (bipy = 2,2′-bipyridine, nbs = 4-nitrobenzenesulfonate).

Solubility
Soluble in toluene, tetrahydrofuran, methylene chloride and ethyl acetate. Insoluble in water.

Notes
Moisture sensitive. Incompatible with strong oxidizing agents and strong bases.
Quantity 500g
Sensitivity Moisture sensitive
Boiling Point 143°C to 144°C (1.5mmHg)
Melting Point 76°C to 80°C
UN Number UN3261
Beilstein 746543
Solubility Information Soluble in toluene,tetrahydrofuran,methylene chloride and ethyl acetate. Insoluble in water.
Formula Weight 221.62
Percent Purity 97%
Chemical Name or Material 4-Nitrobenzenesulfonyl chloride

GHS H Statement
H314-H318
Causes severe skin burns and eye damage.
Causes serious eye damage.

P260-P264b-P280-P301+P330+P331-P303+P361+P353-P304+P340-P305+P351+P338-P310-P363-P501c

H314

DOTInformation : Transport Hazard Class: 8; Packing Group: II; Proper Shipping Name: CORROSIVE SOLID, ACIDIC, ORGANIC, N.O.S.

EINECSNumber : 202-697-9

TSCA : Yes

Recommended Storage : Ambient temperatures; Store under Nitrogen