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4-Thiouridine, 98+% Alfa Aesar™

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Quantity:
100mg
250mg
13957-31-8
C9H12N2O5S
260.264
MFCD00006538
ZLOIGESWDJYCTF-XVFCMESISA-N
4-thiouridine,thiouridine,uridine, 4-thio,1-beta-d-ribofuranosyl-4-thiouracil,1-2r,3r,4s,5r-3,4-dihydroxy-5-hydroxymethyl tetrahydrofuran-2-yl-4-thioxo-3,4-dihydropyrimidin-2 1h-one,1-beta-d-ribofuranosyl-4-thioxo-3,4-dihydropyrimidin-2 1h-one,s4u,thiouridine van,uridine,4-thio,4-thio-d-uridine
3032615
CHEBI:20480
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
C1=CN(C(=O)NC1=S)C2C(C(C(O2)CO)O)O
13957-31-8
C9H12N2O5S
260.264
MFCD00006538
ZLOIGESWDJYCTF-XVFCMESISA-N
4-thiouridine,thiouridine,uridine, 4-thio,1-beta-d-ribofuranosyl-4-thiouracil,1-2r,3r,4s,5r-3,4-dihydroxy-5-hydroxymethyl tetrahydrofuran-2-yl-4-thioxo-3,4-dihydropyrimidin-2 1h-one,1-beta-d-ribofuranosyl-4-thioxo-3,4-dihydropyrimidin-2 1h-one,s4u,thiouridine van,uridine,4-thio,4-thio-d-uridine
3032615
CHEBI:20480
1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-sulfanylidenepyrimidin-2-one
C1=CN(C(=O)NC1=S)C2C(C(C(O2)CO)O)O
Applications
4-Thiouridine is a constituent of several transfer RNA′s. 4-Thiouridine is a thionucleobase used as an antisense agent. Widely used for RNA analysis including RNA-RNA cross coupling and RNA labelling. 4-Thiouridine is a photoreactive (crosslinking) uridine analogue that upon phosphorylation to 4-thioUTP may be incorporated into RNA structures. 4-Thiouridine may be used to study the specificity and kinetics of uridine-cytidine kinases. 4-Thio Uridine is typically used to modify oligos slated for RNA, or RNA-protein, structural studies. A 4-thio-rU modified RNA pentamer was used to study the effect of this modification on codon-anticodon interaction when it is in the wobble position of tRNA.

Solubility
Soluble in water (20 mg/ml), and methanol (10 mg/ml).

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, heat.
Quantity 100mg
Color Yellow
Formula Weight 260.27
Physical Form Crystalline
Percent Purity ≥98%
Chemical Name or Material 4-Thiouridine

Recommended Storage : −30° to −10°C