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Alfa Aesar™ 4alpha-Phorbol 12-myristate 13-acetate, 99%

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Quantity:
1mg
5mg
63597-44-4
C36H56O8
616.836
MFCD00153860
PHEDXBVPIONUQT-LQLWEASQSA-N
4alpha-phorbol 12-myristate 13-acetate,phorbol-12-myristate-13-acetate,pma,4alpha-pma,4alpha-tpa,.alpha.-tpa,4.alpha.-tpa,4alpha-phorbol-12-myristate-13-acetate,4,a-pma,acetoxy-dihydroxy-hydroxymethyl-tetramethyl-oxo-? yl tetradecanoate
122634
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C
63597-44-4
C36H56O8
616.836
MFCD00153860
PHEDXBVPIONUQT-LQLWEASQSA-N
4alpha-phorbol 12-myristate 13-acetate,phorbol-12-myristate-13-acetate,pma,4alpha-pma,4alpha-tpa,.alpha.-tpa,4.alpha.-tpa,4alpha-phorbol-12-myristate-13-acetate,4,a-pma,acetoxy-dihydroxy-hydroxymethyl-tetramethyl-oxo-? yl tetradecanoate
122634
CCCCCCCCCCCCCC(=O)OC1C(C2(C(C=C(CC3(C2C=C(C3=O)C)O)CO)C4C1(C4(C)C)OC(=O)C)O)C

Negative control for phorbol ester activation of protein kinase C

Applications
4alpha-Phorbol 12-myristate 13-acetate is a non-tumor promoting phorbol ester derivative that has been used as a negative control for PMA, a tumor promoter and activator of PKC. However, 4α-PMA has also been shown to be a reasonably potent activator of TRPV4 channels, making it a useful tool for structure-activity investigations via comparison to the very similar compound, 4α-PDD, which demonstrates 50 times more affinity for TRPV4. Furthermore, this compound has also been shown to increase PGHS-2 mRNA significantly in murine keratinocytes.

Solubility
Soluble in DMSO, methanol or ethanol. Dilute stock solution into aqueous medium at final concentrations of ~2-5µM

Notes
Light sensitive. Incompatible with oxidizing agents and heat.
Sensitivity Light Sensitive
Color White
Quantity 5mg
Merck Index 14,7332
Solubility Information Soluble in DMSO, methanol or ethanol; Dilute stock solution into aqueous medium at final concentrations of ∽2 to 5μM
Formula Weight 616.83
Physical Form Powder or Film
Percent Purity 99%
Chemical Name or Material 4alpha-Phorbol 12-myristate 13-acetate

storageNote1 : -30° to -10°C