Protein translation inhibitor; blocks eIF4F subunit interaction
Manufacturer: Tocris 4215/50
DescriptionInhibitor of protein translation; blocks eIF4E:eIF4G and eIF4E:4E-BP1 interaction. Prevents assembly of the eIF4F complex and inhibits cap-dependent translation (IC50 ~4µM). Exhibits chemosensitizing properties.
- Chemical Name: 4-[(3E)-3-[[5-(4-Nitrophenyl)furan-2-yl]methylidene]-2-oxo-5-phenyl-2,3-dihydro-1H-pyrrol-1-yl]benzoic acid
- Formula: C28H18N2O6
- CAS Number: 328998-25-0
- Solubility: Soluble to 50mM in DMSO
- Purity: >98
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